SCHEMBL17028633

SCHEMBL17028633

CCC(Cc1ccc(OCc2cccnc2-c2ccc(C3(C#N)CC3)cc2)cc1)C(=O)O

nearest known ligand 0.73

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 11/20 0.73
PPARA Q07869 4/20 0.37
PPARG P37231 3/20 0.37
PPARD Q03181 1/20 0.37
MAOB P27338 1/20 0.36
PTPN1 P18031 1/20 0.36
FFAR1 O14842 3/20 0.36
ACACB O00763 1/20 0.35
EPHX2 P34913 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17028620 0.85 FFAR4 (1.00) FFAR4FFAR1
SCHEMBL17028635 0.83 FFAR4 (0.68) FFAR4FFAR1ACACB
SCHEMBL17028634 0.81 FFAR4 (0.79) FFAR4FFAR1
SCHEMBL28441594 0.68 PPARA (0.62) FFAR4PPARAPPARGPPARDMAOB
SCHEMBL6208176 0.65 MAOB (0.58) FFAR4MAOB
SCHEMBL17028704 0.65 FFAR4 (0.56) FFAR4PPARAPPARGPPARDFFAR1
SCHEMBL17028529 0.65 FFAR4 (1.00) FFAR4
SCHEMBL17028683 0.64 FFAR4 (1.00) FFAR4FFAR1
SCHEMBL17028712 0.64 FFAR4 (0.59) FFAR4FFAR1
SCHEMBL17028577 0.64 FFAR4 (0.84) FFAR4FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3107901-B1 COMPOUNDS FOR USE AS GPR120 AGONISTS PIRAMAL ENTPR LTD (IN) 2020-04-01 EP disclosed
US-10227360-B2 Compounds for use as GPR120 agonists Piramal Enterprises Limited (IN) 2019-03-12 US disclosed
EP-3107901-A1 COMPOUNDS FOR USE AS GPR120 AGONISTS Piramal Enterprises Limited (IN) 2016-12-28 EP disclosed
US-20160347768-A1 COMPOUNDS FOR USE AS GPR120 AGONISTS Piramal Enterprises Limited (IN) 2016-12-01 US disclosed
WO-2015125085-A1 COMPOUNDS FOR USE AS GPR120 AGONISTS Piramal Enterprises Limited (IN) 2015-08-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10227360-B2 Compounds for use as GPR120 agonists GPR119, GPR55, GPR180 FFAR4 26/4885PPARA 190/4885PPARG 72/4885
US-20160347768-A1 COMPOUNDS FOR USE AS GPR120 AGONISTS GPR119, GPR55, GPR180 FFAR4 26/4885PPARA 190/4885PPARG 72/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.