SCHEMBL17028634

SCHEMBL17028634

CCOC(=O)CCc1ccc(OCc2cccnc2-c2ccc(C3(C#N)CC3)cc2)cc1

nearest known ligand 0.79

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 15/20 0.79
FFAR1 O14842 7/20 0.41
CYP4F2 P78329 1/20 0.37
CYP4A11 Q02928 1/20 0.37
AKR1B1 P15121 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17028620 0.88 FFAR4 (1.00) FFAR4FFAR1AKR1B1
SCHEMBL17028633 0.81 FFAR4 (0.73) FFAR4FFAR1
SCHEMBL17028725 0.80 FFAR4 (0.79) FFAR4FFAR1
SCHEMBL17028635 0.78 FFAR4 (0.68) FFAR4FFAR1
SCHEMBL17028617 0.74 FFAR4 (0.80) FFAR4FFAR1
SCHEMBL17028682 0.71 FFAR4 (0.81) FFAR4FFAR1
SCHEMBL17460606 0.71 FFAR4 (0.76) FFAR4
SCHEMBL17028577 0.71 FFAR4 (0.84) FFAR4FFAR1
SCHEMBL29268072 0.69 CYP4Z1 (0.44) FFAR4CYP4F2CYP4A11
SCHEMBL17028529 0.68 FFAR4 (1.00) FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3107901-B1 COMPOUNDS FOR USE AS GPR120 AGONISTS PIRAMAL ENTPR LTD (IN) 2020-04-01 EP disclosed
US-10227360-B2 Compounds for use as GPR120 agonists Piramal Enterprises Limited (IN) 2019-03-12 US disclosed
EP-3107901-A1 COMPOUNDS FOR USE AS GPR120 AGONISTS Piramal Enterprises Limited (IN) 2016-12-28 EP disclosed
US-20160347768-A1 COMPOUNDS FOR USE AS GPR120 AGONISTS Piramal Enterprises Limited (IN) 2016-12-01 US disclosed
WO-2015125085-A1 COMPOUNDS FOR USE AS GPR120 AGONISTS Piramal Enterprises Limited (IN) 2015-08-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10227360-B2 Compounds for use as GPR120 agonists GPR119, GPR55, GPR180 FFAR4 26/4885FFAR1 11/4885CYP4F2 545/4885
US-20160347768-A1 COMPOUNDS FOR USE AS GPR120 AGONISTS GPR119, GPR55, GPR180 FFAR4 26/4885FFAR1 11/4885CYP4F2 545/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.