Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.71 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5823375 | 0.86 | BCHE (0.69) | BCHEPTGS2ALDH1A1ALOX15LMNA | |
| SCHEMBL17034707 | 0.83 | BCHE (0.65) | BCHEPTGS2ALDH1A1ALOX15MGLL | |
| Ampyrone SCHEMBL11674586 | 0.83 | BCHE (1.00) | BCHEPTGS2ALDH1A1ALOX15HSP90AA1 | |
| Ampyrone SCHEMBL128544 | 0.83 | BCHE (1.00) | BCHEPTGS2ALDH1A1ALOX15HSP90AA1 | |
| Ampyrone SCHEMBL18159502 | 0.83 | BCHE (1.00) | BCHEPTGS2ALDH1A1ALOX15HSP90AA1 | |
| SCHEMBL23401173 | 0.83 | BCHE (0.59) | BCHEPTGS2ALDH1A1ALOX15HSP90AA1 | |
| SCHEMBL23400760 | 0.83 | BCHE (0.59) | BCHEPTGS2ALDH1A1ALOX15HSP90AA1 | |
| Ampyrone SCHEMBL10746988 | 0.81 | BCHE (0.96) | BCHEPTGS2ALDH1A1ALOX15HSP90AA1 | |
| Ampyrone SCHEMBL1830291 | 0.81 | BCHE (0.96) | BCHEPTGS2ALDH1A1ALOX15HSP90AA1 | |
| SCHEMBL18334470 | 0.81 | PTGS2 (0.61) | BCHEPTGS2ALDH1A1TSHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170107207-A1 | AMINOPYRAZOLONE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2017-04-20 | — | — | US | disclosed |
| US-20170107207-A1 | AMINOPYRAZOLONE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2017-04-20 | — | — | US | disclosed |
| US-20170107207-A1 | AMINOPYRAZOLONE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2017-04-20 | — | — | US | disclosed |
| US-20170088546-A1 | CARBOXAMIDE INHIBITORS | NOVARTIS AG (CH) | 2017-03-30 | — | — | US | disclosed |
| US-20170088546-A1 | CARBOXAMIDE INHIBITORS | NOVARTIS AG (CH) | 2017-03-30 | — | — | US | disclosed |
| US-20170088546-A1 | CARBOXAMIDE INHIBITORS | NOVARTIS AG (CH) | 2017-03-30 | — | — | US | disclosed |
| EP-3109239-A1 | AMINOPYRAZOLONE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2016-12-28 | — | — | EP | disclosed |
| WO-2015173659-A2 | CARBOXAMIDE DERIVATIVES | NOVARTIS AG (CH) | 2015-11-19 | — | — | WO | disclosed |
| WO-2015125786-A1 | AMINOPYRAZOLONE DERIVATIVE | 第一三共株式会社 | 2015-08-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170088546-A1 | CARBOXAMIDE INHIBITORS | SMURF1, SMURF2, SMYD2 | BCHE 4333/4885PTGS2 2129/4885ALDH1A1 1440/4885 |
| US-20170107207-A1 | AMINOPYRAZOLONE DERIVATIVE | ATAD5, ATP1A1, TIPRL | BCHE 4205/4885PTGS2 3518/4885ALDH1A1 2821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.