Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Ampyrone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE known ✓ | P06276 | 1/20 | 0.96 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.96 |
| ▸ | HSP90AA1 known ✓ | P07900 | 1/20 | 0.50 |
| ▸ | HSP90AB1 known ✓ | P08238 | 1/20 | 0.50 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | THRB | P10828 | 2/20 | 0.58 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ampyrone SCHEMBL10746988 | 1.00 | BCHE (0.96) | BCHEPTGS2ALOX15ALDH1A1LMNA | |
| Ampyrone SCHEMBL11674586 | 0.98 | BCHE (1.00) | BCHEPTGS2ALOX15ALDH1A1LMNA | |
| Ampyrone SCHEMBL18159502 | 0.98 | BCHE (1.00) | BCHEPTGS2ALOX15ALDH1A1LMNA | |
| Ampyrone SCHEMBL128544 | 0.98 | BCHE (1.00) | BCHEPTGS2ALOX15ALDH1A1LMNA | |
| Ampyrone SCHEMBL28606780 | 0.90 | BCHE (0.84) | BCHEPTGS2ALOX15ALDH1A1LMNA | |
| Ampyrone SCHEMBL3092850 | 0.90 | BCHE (0.84) | BCHEPTGS2ALOX15ALDH1A1LMNA | |
| Ampyrone SCHEMBL10711697 | 0.89 | BCHE (0.82) | BCHEPTGS2ALOX15ALDH1A1LMNA | |
| Ampyrone SCHEMBL4542675 | 0.88 | BCHE (0.79) | BCHEPTGS2ALOX15ALDH1A1LMNA | |
| Ampyrone SCHEMBL28982549 | 0.88 | BCHE (0.79) | BCHEPTGS2ALOX15ALDH1A1LMNA | |
| Ampyrone SCHEMBL8624284 | 0.88 | BCHE (0.79) | BCHEPTGS2ALOX15ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 118 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118717774-A | Preparation method of small molecular compound GI-Y3 and application of small molecular compound GI-Y3 in preparation of anti-cell apoptosis drugs and inhibitors | 温州医科大学附属第一医院 | 2024-10-01 | — | — | CN | claimed |
| CN-117625733-A | Lactic acid detection freeze-dried reagent ball, preparation method and microfluidic detection chip | 诺迈(苏州)科技有限公司 | 2024-03-01 | — | — | CN | claimed |
| CN-114200122-B | Uric acid detection freeze-dried reagent ball, configuration method thereof and microfluidic detection chip | 深圳市锦瑞生物科技股份有限公司 | 2023-09-15 | — | — | CN | claimed |
| CN-114200122-A | Freeze-dried reagent ball for uric acid detection, configuration method thereof and microfluidic detection chip | 深圳市锦瑞生物科技股份有限公司 | 2022-03-18 | — | — | CN | claimed |
| US-9574221-B2 | Method for the determination of the concentration of vitamin B6 in a sample | BÜHLMANN LABORATORIES AG (CH) | 2017-02-21 | — | — | US | claimed |
| EP-2533053-B1 | Method for the determination of the concentration of vitamin B6 in a sample | BÜHLMANN LAB AG (CH) | 2015-09-09 | — | — | EP | claimed |
| US-20140308691-A1 | METHOD FOR THE DETERMINATION OF THE CONCENTRATION OF VITAMIN B6 IN A SAMPLE | BUEHLMANN LABORATORIES AG (CH) | 2014-10-16 | — | — | US | claimed |
| WO-2012168470-A1 | METHOD FOR THE DETERMINATION OF THE CONCENTRATION OF VITAMIN B6 IN A SAMPLE | BÜHLMANN LABORATORIES AG (CH) | 2012-12-13 | — | — | WO | claimed |
| EP-2533053-A1 | Method for the determination of the concentration of vitamin B6 in a sample | Bühlmann Laboratories AG (CH) | 2012-12-12 | — | — | EP | claimed |
| US-4283491-A | ADDITION COPOLYMERS FOR IMPROVED STORAGE OR PEROXIDASE REAGENT | EASTMAN KODAK COMPANY (US) | 1981-08-11 | — | — | US | claimed |
| CN-118717774-A | Preparation method of small molecular compound GI-Y3 and application of small molecular compound GI-Y3 in preparation of anti-cell apoptosis drugs and inhibitors | 温州医科大学附属第一医院 | 2024-10-01 | — | — | CN | disclosed |
| CN-117625733-A | Lactic acid detection freeze-dried reagent ball, preparation method and microfluidic detection chip | 诺迈(苏州)科技有限公司 | 2024-03-01 | — | — | CN | disclosed |
| CN-114200122-B | Uric acid detection freeze-dried reagent ball, configuration method thereof and microfluidic detection chip | 深圳市锦瑞生物科技股份有限公司 | 2023-09-15 | — | — | CN | disclosed |
| CN-114200122-B | Uric acid detection freeze-dried reagent ball, configuration method thereof and microfluidic detection chip | 深圳市锦瑞生物科技股份有限公司 | 2023-09-15 | — | — | CN | disclosed |
| CN-114200122-A | Freeze-dried reagent ball for uric acid detection, configuration method thereof and microfluidic detection chip | 深圳市锦瑞生物科技股份有限公司 | 2022-03-18 | — | — | CN | disclosed |
| US-4166093-A | REDUCTION OF DETECTABLE SPECIES MIGRATION IN ELEMENTS FOR THE ANALYSIS OF LIQUIDS | EASTMAN KODAK COMPANY (US) | 1979-08-28 | — | — | US | disclosed |
| US-4098574-A | BUFFERED TRINDER'S REAGENT | EASTMAN KODAK COMPANY (US) | 1978-07-04 | — | — | US | disclosed |
| US-4066403-A | DECOMPOSITION, PERMEABLE BARRIERS | EASTMAN KODAK COMPANY (US) | 1978-01-03 | — | — | US | disclosed |
| US-4042461-A | HYDROPHOBIC CHROMATOGRAPHY | EASTMAN KODAK COMPANY (US) | 1977-08-16 | — | — | US | disclosed |
| US-3983005-A | Integral element for the analysis of cholesterol | EASTMAN KODAK COMPANY (US) | 1976-09-28 | — | — | US | disclosed |