Succinic Acid

Succinic Acid

SCHEMBL1704049

CC[P+](c1ccc(C)cc1)(c1ccc(C)cc1)c1ccc(C)cc1.CC[P+](c1ccc(C)cc1)(c1ccc(C)cc1)c1ccc(C)cc1.O=C([O-])CCC(=O)[O-]

nearest known ligand 0.38

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4

The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.38
HDAC3 O15379 3/20 0.37
HDAC1 Q13547 3/20 0.37
HDAC2 Q92769 3/20 0.37
HDAC8 Q9BY41 3/20 0.37
FFAR3 O14843 2/20 0.37
ALDH1A1 P00352 3/20 0.36
LMNA P02545 2/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
HPGD P15428 1/20 0.36
KMT2A Q03164 1/20 0.35
CES2 O00748 1/20 0.34
CES1 P23141 1/20 0.34
HDAC4 P56524 1/20 0.34
HDAC7 Q8WUI4 1/20 0.34
HDAC10 Q969S8 1/20 0.34
HDAC11 Q96DB2 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34
HDAC9 Q9UKV0 1/20 0.34
HDAC5 Q9UQL6 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL2170900 0.89 ALDH1A1 (0.38) ALDH1A1LMNASMN1; SMN2CES2CES1
Acetic Acid SCHEMBL7053062 0.89 ALDH1A1 (0.38) ALDH1A1LMNASMN1; SMN2CES2CES1
Acetic Acid SCHEMBL6755875 0.85 ALDH1A1 (0.38) ALDH1A1LMNASMN1; SMN2KMT2ACES2
Succinic Acid SCHEMBL679440 0.83 CYP2C19 (0.50) CA1HDAC3HDAC1HDAC2HDAC8
Succinic Acid SCHEMBL7197891 0.82 SNCA (0.39) HDAC3HDAC1HDAC2HDAC8ALDH1A1
Succinic Acid SCHEMBL7195809 0.80 HPGD (0.38) HDAC3HDAC1HDAC2HDAC8LMNA
Succinic Acid SCHEMBL7192904 0.80 ALDH1A1 (0.36) CA1HDAC3HDAC1HDAC2HDAC8
Iodide SCHEMBL7192916 0.80 ACHE (0.42) CA1ALDH1A1LMNASMN1; SMN2CA2
Bromide SCHEMBL5074601 0.80 ACHE (0.42) CA1ALDH1A1LMNASMN1; SMN2CA2
Hydrochloric Acid SCHEMBL7196441 0.80 ACHE (0.42) CA1ALDH1A1LMNASMN1; SMN2CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2585473-B1 METAL PHOSPHONATE FLAME RETARDANT AND METHOD PRODUCING THEREOF ICL IP AMERICA INC (US) 2015-09-23 EP claimed
US-8889773-B2 Metal phosphonate flame retardant and method producing thereof ICL-IP AMERICA INC. (US) 2014-11-18 US claimed
US-20130165564-A1 METAL PHOSPHONATE FLAME RETARDANT AND METHOD PRODUCING THEREOF ICL-IP AMERICA INC. (US) 2013-06-27 US claimed
WO-2013077989-A1 PROCESS FOR PREPARATION OF ALUMINUM SALT OF PHOSPHONIC ACID ESTER ICL-IP AMERICA INC. (US) 2013-05-30 WO claimed
EP-2585473-A2 METAL PHOSPHONATE FLAME RETARDANT AND METHOD PRODUCING THEREOF ICL-IP America Inc. (US) 2013-05-01 EP claimed
WO-2011163207-A2 METAL PHOSPHONATE FLAME RETARDANT AND METHOD PRODUCING THEREOF ICL-IP AMERICA INC. (US) 2011-12-29 WO claimed
WO-2008045884-A1 PROCESS FOR PREPARING SOLUBLE POLYMERS WITH HIGH CONVERSION OF ACID FROM AROMATIC EPOXY RESINS AND DIACIDS AND PROCESS FOR PREPARING CROSSLINKED COATINGS THEREFROM DOW GLOBAL TECHNOLOGIES INC. (US) 2008-04-17 WO claimed
WO-2008045889-A1 PROCESS FOR PREPARING SOLUBLE POLYMERS WITH LOW CONVERSION OF ACID FROM AROMATIC EPOXY RESINS AND DIACIDS AND PROCESS FOR PREPARING CROSSLINKED COATINGS THEREFROM DOW GLOBAL TECHNOLOGIES INC. (US) 2008-04-17 WO claimed
US-6555628-B2 Controlled conversion resins derived from reacting epoxy resin, dihydric phenol, acid anhydride, and/or amine; protective/powder coatings DOW GLOBAL TECHNOLOGIES INC. 2003-04-29 US claimed
EP-0624173-B2 PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS DOW CHEMICAL CO (US) 2003-04-09 EP claimed
US-20020128428-A1 Epoxy resins and process for making the same DOW DEUTSCHLAND INC. (DE) 2002-09-12 US claimed
EP-0624173-A1 PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS. DOW CHEMICAL CO (US) 1994-11-17 EP claimed
WO-1993015126-A1 PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS THE DOW CHEMICAL COMPANY (US) 1993-08-05 WO claimed
US-5202407-A Phosphonium or phosphine catalyst having at least three alkylphenyl groups attached to phosphorus atom THE DOW CHEMICAL COMPANY (US) 1993-04-13 US claimed
EP-2585473-B1 METAL PHOSPHONATE FLAME RETARDANT AND METHOD PRODUCING THEREOF ICL IP AMERICA INC (US) 2015-09-23 EP disclosed
US-20150159040-A1 LOW-VISCOSITY PHENOLIC DIGLYCIDYL ETHERS FOR EPOXY COATING APPLICATIONS BLUE CUBE IP LLC 2015-06-11 US disclosed
EP-2859030-A2 LOW-VISCOSITY PHENOLIC DIGLYCIDYL ETHERS FOR EPOXY COATING APPLICATIONS Dow Global Technologies LLC (US) 2015-04-15 EP disclosed
EP-0624173-A1 PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS. DOW CHEMICAL CO (US) 1994-11-17 EP disclosed
WO-1993015126-A1 PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS THE DOW CHEMICAL COMPANY (US) 1993-08-05 WO disclosed
US-5202407-A Phosphonium or phosphine catalyst having at least three alkylphenyl groups attached to phosphorus atom THE DOW CHEMICAL COMPANY (US) 1993-04-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130165564-A1 METAL PHOSPHONATE FLAME RETARDANT AND METHOD PRODUCING THEREOF MTAP, AS3MT, MPHOSPH6 CA1 394/4885HDAC3 2460/4885HDAC1 1972/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.