Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 12/20 | 0.49 |
| ▸ | SYK | P43405 | 2/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | WNT3A | P56704 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1705279 | 0.89 | GRM1 (0.47) | KARS1GRM5GRM1NAMPTWNT3A | |
| SCHEMBL901312 | 0.88 | KARS1 (0.54) | KARS1SYK | |
| SCHEMBL1704989 | 0.86 | NAMPT (0.44) | GRM5GRM1NAMPTJAK1 | |
| SCHEMBL901343 | 0.85 | NAMPT (0.44) | SYKGRM5GRM1NAMPTWNT3A | |
| SCHEMBL902272 | 0.81 | SYK (0.53) | KARS1SYKWNT3A | |
| SCHEMBL901697 | 0.81 | KARS1 (0.65) | KARS1SYK | |
| SCHEMBL1704352 | 0.80 | GRM1 (0.46) | KARS1SYKGRM5GRM1NAMPT | |
| SCHEMBL901325 | 0.80 | GRM1 (0.50) | GRM5GRM1NAMPTJAK1 | |
| SCHEMBL901674 | 0.78 | KARS1 (0.62) | KARS1SYK | |
| SCHEMBL7831576 | 0.78 | PDK4 (0.58) | GRM5GRM1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |