Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 12/20 | 0.54 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.44 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704197 | 0.88 | KARS1 (0.49) | KARS1SYK | |
| SCHEMBL902090 | 0.87 | KARS1 (0.55) | KARS1SYKKMO | |
| SCHEMBL1704842 | 0.87 | KARS1 (0.52) | KARS1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1704967 | 0.83 | ALDH1A1 (0.44) | KARS1MAP3K12ALDH1A1SMN1; SMN2JAK2 | |
| SCHEMBL902774 | 0.83 | ALDH1A1 (0.37) | KARS1ALDH1A1SMN1; SMN2 | |
| SCHEMBL901929 | 0.79 | KARS1 (0.55) | KARS1MAP3K12SYK | |
| SCHEMBL1704662 | 0.79 | KARS1 (0.72) | KARS1MAP3K12SYKALDH1A1SMN1; SMN2 | |
| SCHEMBL901948 | 0.78 | KARS1 (0.46) | KARS1SYKALDH1A1SMN1; SMN2 | |
| SCHEMBL901243 | 0.77 | KARS1 (0.59) | KARS1SYK | |
| SCHEMBL901679 | 0.76 | MAPT (0.46) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |