Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 3/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.38 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704643 | 0.87 | MAPT (0.47) | KARS1SYKKITPIK3CAGPR119 | |
| SCHEMBL902044 | 0.87 | KARS1 (0.51) | KARS1SYKADORA2AMEN1KMT2A | |
| SCHEMBL901333 | 0.86 | KARS1 (0.65) | KARS1SYKKITGPR119CKS1B | |
| SCHEMBL902983 | 0.79 | KARS1 (0.64) | KARS1SYKKITPIK3CAGPR119 | |
| SCHEMBL1704491 | 0.79 | KARS1 (0.70) | KARS1 | |
| SCHEMBL1704430 | 0.77 | KARS1 (0.49) | KARS1SYKJAK1WNT3ACDK9 | |
| SCHEMBL1705093 | 0.76 | KARS1 (0.53) | KARS1SYKGPR119 | |
| SCHEMBL1704675 | 0.76 | KARS1 (0.51) | KARS1SYKGPR119WNT3A | |
| SCHEMBL1704732 | 0.75 | KARS1 (0.52) | KARS1SYKGPR119CKS1BSKP1 | |
| SCHEMBL902995 | 0.75 | KARS1 (0.67) | KARS1SYKGPR119WNT3ACKS1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |