Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 3/20 | 0.49 |
| ▸ | GRM1 | Q13255 | 6/20 | 0.45 |
| ▸ | GRM5 | P41594 | 5/20 | 0.45 |
| ▸ | WNT3A | P56704 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10269155 | 0.88 | WNT3A (0.43) | KARS1GRM1GRM5WNT3ASYK | |
| SCHEMBL901761 | 0.88 | KARS1 (0.54) | KARS1CDK9 | |
| SCHEMBL1704352 | 0.83 | GRM1 (0.46) | KARS1GRM1GRM5WNT3ASYK | |
| SCHEMBL901333 | 0.82 | KARS1 (0.65) | KARS1SYK | |
| SCHEMBL1705279 | 0.81 | GRM1 (0.47) | KARS1GRM1GRM5WNT3AJAK1 | |
| SCHEMBL1705115 | 0.79 | KARS1 (0.55) | KARS1GRM1GRM5WNT3AJAK1 | |
| SCHEMBL1704574 | 0.78 | KARS1 (0.48) | KARS1GRM1GRM5WNT3AJAK1 | |
| SCHEMBL1704429 | 0.77 | KARS1 (0.46) | KARS1WNT3ASYKJAK1CDK9 | |
| SCHEMBL901565 | 0.75 | KARS1 (0.42) | KARS1CDK9 | |
| SCHEMBL901564 | 0.75 | KARS1 (0.42) | KARS1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |