Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.38 |
| ▸ | ITGAL | P20701 | 2/20 | 0.38 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.37 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.37 |
| ▸ | NEK2 | P51955 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704536 | 0.89 | LMNA (0.45) | LMNASMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL1704917 | 0.86 | LMNA (0.43) | LMNASMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL901397 | 0.83 | KARS1 (0.55) | KDM4EKARS1 | |
| SCHEMBL901952 | 0.80 | LMNA (0.45) | LMNASMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL1705038 | 0.76 | CCNT1 (0.41) | KMT2AKARS1PRKD1PRKD2NEK2 | |
| SCHEMBL1704646 | 0.76 | GPR119 (0.42) | LMNAMAPTL3MBTL1 | |
| SCHEMBL901378 | 0.76 | LMNA (0.66) | LMNASMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL1704616 | 0.74 | KARS1 (0.53) | KDM4EKARS1 | |
| SCHEMBL902918 | 0.72 | KARS1 (0.58) | KDM4EKARS1PRKD1PRKD2 | |
| SCHEMBL902088 | 0.72 | KARS1 (0.56) | KARS1PRKD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |