Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYCR1 | P32322 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR1E | P28566 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2221665 | 0.81 | CASP1 (0.34) | ALDH1A1MAPTLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL29499603 | 0.81 | CASP1 (0.34) | ALDH1A1MAPTLMNAMAPK1SMN1; SMN2 | |
| Ammonia Solution, Strong SCHEMBL5991120 | 0.80 | CASP1 (0.33) | ALDH1A1MAPTLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL10626050 | 0.79 | KMT2A (0.50) | HTR1AADRA2ADRD2ADRA2BADRA2C | |
| SCHEMBL17047670 | 0.76 | S100B (0.44) | ALDH1A1MAPTLMNAMAPK1TSHR | |
| SCHEMBL25641569 | 0.75 | PYCR1 (0.39) | PYCR1HTR1AADRA2ADRD2ADRA2B | |
| SCHEMBL556848 | 0.73 | C5AR1 (0.37) | ALDH1A1LMNASMN1; SMN2TSHRKDM4E | |
| SCHEMBL17047624 | 0.73 | ALDH3A1 (0.46) | SLC6A2CRHR1ALDH1A1MAPTKDM4E | |
| SCHEMBL9999846 | 0.72 | ALDH1A1 (0.40) | CRHR1ALDH1A1MAPTMAPK1TSHR | |
| SCHEMBL16388499 | 0.71 | HRH4 (0.35) | HTR2AHTR2CALDH1A1TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10301258-B2 | Benzende sulfonamide derivatives as HIV integrase inhibitors | HOWARD UNIVERSITY (US) | 2019-05-28 | — | — | US | disclosed |
| US-20170008839-A1 | BENZENDE SULFONAMIDE DERIVATIVES AS HIV INTEGRASE INHIBITORS | HOWARD UNIVERSITY (US) | 2017-01-12 | — | — | US | disclosed |
| WO-2015130947-A1 | BENZENDE SULFONAMIDE DERIVATIVES AS HIV INTEGRASE INHIBITORS | HOWARD UNIVERSITY (US) | 2015-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170008839-A1 | BENZENDE SULFONAMIDE DERIVATIVES AS HIV INTEGRASE INHIBITORS | NR2E3, NR2E1, PIM3 | PYCR1 1933/4885HTR1A 2723/4885ADRA2A 2210/4885 |
| US-10301258-B2 | Benzende sulfonamide derivatives as HIV integrase inhibitors | NR2E3, NR2E1, PIM3 | PYCR1 1933/4885HTR1A 2723/4885ADRA2A 2210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.