Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17118118 | 1.00 | PSEN1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2014327 | 0.83 | PSEN1 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL812651 | 0.83 | PSEN1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2013946 | 0.81 | ATM (0.37) | ALDH1A1MAPTGAAKMT2ATSHR | |
| SCHEMBL2505350 | 0.81 | ATM (0.37) | ALDH1A1MAPTGAAKMT2ATSHR | |
| SCHEMBL19759347 | 0.77 | MAPK1 (0.39) | GAA | |
| SCHEMBL2017466 | 0.75 | SLC1A2 (0.34) | MEN1KMT2AHTT | |
| SCHEMBL17110217 | 0.75 | AKR1B10 (0.36) | SMN1; SMN2ALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL2017042 | 0.75 | SLC1A2 (0.34) | MEN1KMT2AHTT | |
| SCHEMBL294716 | 0.73 | LMNA (0.43) | ALDH1A1MAPTKDM4EMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240417386-A1 | INHIBITORS OF RET | MIDCAP FINANCIAL TRUST | 2024-12-19 | — | — | US | disclosed |
| EP-4331585-A2 | INHIBITORS OF RET | Blueprint Medicines Corporation (US) | 2024-03-06 | — | — | EP | disclosed |
| EP-4292594-A2 | INHIBITORS OF RET | Blueprint Medicines Corporation (US) | 2023-12-20 | — | — | EP | disclosed |
| EP-3371171-B1 | INHIBITORS OF RET | BLUEPRINT MEDICINES CORP (US) | 2023-10-25 | — | — | EP | disclosed |
| EP-3371171-B1 | INHIBITORS OF RET | BLUEPRINT MEDICINES CORP (US) | 2023-10-25 | — | — | EP | disclosed |
| CN-111423416-B | Inhibitors of RET | 缆图药品公司 | 2023-05-26 | — | — | CN | disclosed |
| US-20220315560-A1 | INHIBITORS OF RET | BLUEPRINT MEDICINES CORPORATION | 2022-10-06 | — | — | US | disclosed |
| US-11279688-B2 | Inhibitors of RET | BLUEPRINT MEDICINES CORPORATION (US) | 2022-03-22 | — | — | US | disclosed |
| US-20200407341-A1 | INHIBITORS OF RET | BLUEPRINT MEDICINES CORPORATION | 2020-12-31 | — | — | US | disclosed |
| CN-111423416-A | Inhibitors of RET | 蓝图药品公司 | 2020-07-17 | — | — | CN | disclosed |
| EP-3110810-B1 | PYRAZOLE AMIDE DERIVATIVE | TEIJIN PHARMA LTD (JP) | 2018-05-02 | — | — | EP | disclosed |
| WO-2017079140-A1 | INHIBITORS OF RET | BLUEPRINT MEDICINES CORPORATION (US) | 2017-05-11 | — | — | WO | disclosed |
| WO-2017079140-A1 | INHIBITORS OF RET | BLUEPRINT MEDICINES CORPORATION (US) | 2017-05-11 | — | — | WO | disclosed |
| US-20170121312-A1 | INHIBITORS OF RET | BLUEPRINT MEDICINES CORPORATION | 2017-05-04 | — | — | US | disclosed |
| US-20170121312-A1 | INHIBITORS OF RET | BLUEPRINT MEDICINES CORPORATION | 2017-05-04 | — | — | US | disclosed |
| US-20170121312-A1 | INHIBITORS OF RET | BLUEPRINT MEDICINES CORPORATION | 2017-05-04 | — | — | US | disclosed |
| EP-3110810-A1 | PYRAZOLE AMIDE DERIVATIVE | Teijin Pharma Limited (JP) | 2017-01-04 | — | — | EP | disclosed |
| US-9365522-B2 | Pyrazole amide derivative | AMGEN INC. (US) | 2016-06-14 | — | — | US | disclosed |
| US-20150266824-A1 | Pyrazole Amide Derivative | TEIJIN LIMITED (JP) | 2015-09-24 | — | — | US | disclosed |
| WO-2015129926-A1 | PYRAZOLE AMIDE DERIVATIVE | TEIJIN PHARMA LIMITED (JP) | 2015-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240417386-A1 | INHIBITORS OF RET | RET, HRAS, RB1 | PSEN1 1989/4885PSEN2 1289/4885APH1B 1933/4885 |
| US-11279688-B2 | Inhibitors of RET | RET, HRAS, RB1 | PSEN1 1989/4885PSEN2 1289/4885APH1B 1933/4885 |
| US-20150266824-A1 | Pyrazole Amide Derivative | RORC, RORB, RORA | PSEN1 4571/4885PSEN2 4516/4885APH1B 2905/4885 |
| US-20200407341-A1 | INHIBITORS OF RET | RET, HRAS, RB1 | PSEN1 1989/4885PSEN2 1289/4885APH1B 1933/4885 |
| US-20170121312-A1 | INHIBITORS OF RET | RET, HRAS, RB1 | PSEN1 1989/4885PSEN2 1289/4885APH1B 1933/4885 |
| US-20220315560-A1 | INHIBITORS OF RET | RET, HRAS, RB1 | PSEN1 1989/4885PSEN2 1289/4885APH1B 1933/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.