SCHEMBL1705451

SCHEMBL1705451

[CH2]CSc1ccc(Cl)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.47
ALDH1A1 P00352 3/20 0.47
RAB9A P51151 3/20 0.47
MEN1 O00255 3/20 0.47
NPC1 O15118 2/20 0.47
MAPT P10636 3/20 0.42
IDO1 P14902 1/20 0.42
MAOA P21397 1/20 0.42
MAOB P27338 1/20 0.42
SOD1 P00441 1/20 0.42
LMNA P02545 2/20 0.42
CYP2A6 P11509 1/20 0.42
HTT P42858 3/20 0.42
POLB P06746 3/20 0.42
HPGD P15428 3/20 0.42
L3MBTL1 Q9Y468 2/20 0.42
ALOX15 P16050 1/20 0.42
ALOX12 P18054 1/20 0.42
NR4A1 P22736 1/20 0.42
MCL1 Q07820 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1739830 0.80 TEAD1 (0.47) KMT2AALDH1A1RAB9AMEN1NPC1
SCHEMBL9808062 0.78 TEAD1 (0.53) KMT2AALDH1A1RAB9AMEN1NPC1
SCHEMBL10981879 0.78 KMT2A (0.50) KMT2AALDH1A1RAB9AMEN1NPC1
SCHEMBL5974847 0.77 KDM4E (0.49) KMT2AALDH1A1RAB9AMEN1NPC1
SCHEMBL907105 0.76 KMT2A (0.48) KMT2AALDH1A1RAB9AMEN1NPC1
SCHEMBL9546524 0.74 KMT2A (0.47) KMT2AALDH1A1RAB9AMEN1NPC1
SCHEMBL14666345 0.74 KMT2A (0.47) KMT2AALDH1A1RAB9AMEN1NPC1
SCHEMBL1739588 0.74 MAOA (0.42) KMT2AALDH1A1RAB9AMEN1NPC1
SCHEMBL9808024 0.74 KDM4E (0.59) KMT2AALDH1A1RAB9AMEN1NPC1
SCHEMBL194788 0.74 NR1H2 (0.50) KMT2AALDH1A1RAB9AMEN1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 211 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014011540-A1 BONE MORPHOGENETIC PROTEIN PATHWAY ACTIVATION, COMPOSITIONS FOR OSSIFICATION, AND METHODS RELATED THERETO EMORY UNIVERSITY (US) 2014-01-16 WO claimed
US-20120301426-A1 ALKANOYLAMINO BENZAMIDE ANILINE HDAC INHIBITOR COMPOUNDS GILEAD SCIENCES, INC. (US) 2012-11-29 US claimed
EP-2440519-A1 ALKANOYLAMINO BENZAMIDE ANILINE HDAC INIHIBITOR COMPOUNDS Gilead Sciences, Inc. (US) 2012-04-18 EP claimed
WO-2010144371-A1 ALKANOYLAMINO BENZAMIDE ANILINE HDAC INIHIBITOR COMPOUNDS GILEAD COLORADO, INC. (US) 2010-12-16 WO claimed
US-20100310500-A1 ALKANOYLAMINO BENZAMIDE ANILINE HDAC INHIBITOR COMPOUNDS GILEAD SCIENCES, INC. (US) 2010-12-09 US claimed
EP-1879567-A1 AMINO ACID DERIVATIVES Pfizer Limited (GB) 2008-01-23 EP claimed
US-20060247291-A1 Amino acid derivatives PFIZER, INC. 2006-11-02 US claimed
WO-2006114707-A1 AMINO ACID DERIVATIVES PFIZER LIMITED (GB) 2006-11-02 WO claimed
US-4579971-A HERBICIDES NIPPON SODA CO. LTD. (JP) 1986-04-01 US claimed
US-4249937-A 2-(1-ALKYLOXYAMINO-ALKYLIDENE)-5-(ALKYL OR ARYL-SULFENYL, SULFINYL-ALKYL)-1,3-CYCLOHEXADIONE HERBICIDES NIPPON SODA COMPANY, LTD. (JP) 1981-02-10 US claimed
US-20240239922-A1 PHOTOCURABLE COMPOSITION TOKYO OHKA KOGYO CO., LTD. (JP) 2024-07-18 US disclosed
US-20240192593-A1 PHOTOSENSITIVE COMPOSITION TOKYO OHKA KOGYO CO., LTD. (JP) 2024-06-13 US disclosed
US-20240191003-A1 COMPOSITION AND PHOTOSENSITIVE COMPOSITION TOKYO OHKA KOGYO CO., LTD. (JP) 2024-06-13 US disclosed
US-11981794-B2 Curable composition, cured product, and compound TOKYO OHKA KOGYO CO., LTD. (JP) 2024-05-14 US disclosed
CN-117999296-A Composition and photosensitive composition 东京应化工业株式会社 2024-05-07 CN disclosed
US-4579971-A HERBICIDES NIPPON SODA CO. LTD. (JP) 1986-04-01 US disclosed
US-4579971-A HERBICIDES NIPPON SODA CO. LTD. (JP) 1986-04-01 US disclosed
US-4177350-A FUNGICIDES SIEGFRIED AKTIENGESELLSCHAFT (CH) 1979-12-04 US disclosed
US-4154945-A Fungicidal substituted imidazoles THE BOOTS COMPANY LIMITED (GB) 1979-05-15 US disclosed
US-4080462-A Fungicidal compositions containing substituted imidazoles THE BOOTS COMPANY LIMITED (EN) 1978-03-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060247291-A1 Amino acid derivatives OPRL1, BCAT2, BCAT1 KMT2A 1916/4885ALDH1A1 1189/4885RAB9A 1647/4885
US-20100310500-A1 ALKANOYLAMINO BENZAMIDE ANILINE HDAC INHIBITOR COMPOUNDS HDAC1, HDAC5, HDAC7 KMT2A 47/4885ALDH1A1 339/4885RAB9A 3213/4885
US-20120301426-A1 ALKANOYLAMINO BENZAMIDE ANILINE HDAC INHIBITOR COMPOUNDS HDAC1, HDAC5, HDAC7 KMT2A 47/4885ALDH1A1 339/4885RAB9A 3213/4885
US-20240192593-A1 PHOTOSENSITIVE COMPOSITION PPOX, ERCC1, ERCC5 KMT2A 666/4885ALDH1A1 1414/4885RAB9A 2620/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.