Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNASE1 | P07998 | 1/20 | 0.37 |
| ▸ | TK1 | P04183 | 5/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
| ▸ | TK2 | O00142 | 2/20 | 0.33 |
| ▸ | TYMP | P19971 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1706305 | 0.96 | RNASE1 (0.38) | RNASE1TK1TOP2ATK2 | |
| SCHEMBL9755145 | 0.94 | RNASE1 (0.38) | RNASE1TK1TOP2ATK2 | |
| SCHEMBL1705935 | 0.92 | RNASE1 (0.35) | RNASE1TK1TOP2ATK2 | |
| SCHEMBL8920654 | 0.90 | RNASE1 (0.36) | RNASE1TK1TOP2ATK2 | |
| SCHEMBL7640415 | 0.88 | RNASE1 (0.38) | RNASE1TK1TK2 | |
| SCHEMBL20636773 | 0.87 | LMNA (0.38) | RNASE1TOP2A | |
| SCHEMBL3612838 | 0.87 | TK1 (0.38) | RNASE1TK1 | |
| SCHEMBL1727535 | 0.87 | RNASE1 (0.40) | RNASE1TK1TK2 | |
| SCHEMBL8370048 | 0.85 | RNASE1 (0.38) | RNASE1TK1TK2 | |
| SCHEMBL7863893 | 0.83 | RNASE1 (0.37) | RNASE1TK1TOP2ATK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8825411-B2 | Design, synthesis and assembly of synthetic nucleic acids | DNA TWOPOINTO, INC. (US) | 2014-09-02 | — | — | US | disclosed |
| EP-2441769-B1 | Design, synthesis and assembly of synthetic nucleic acids | REPLIGEN CORP (US) | 2014-05-07 | — | — | EP | disclosed |
| US-20130196864-A1 | DESIGN, SYNTHESIS AND ASSEMBLY OF SYNTHETIC NUCLEIC ACIDS | DNA TWOPOINTO, INC. (US) | 2013-08-01 | — | — | US | disclosed |
| EP-2441769-A1 | Design, synthesis and assembly of synthetic nucleic acids | REPLIGEN CORPORATION (US) | 2012-04-18 | — | — | EP | disclosed |
| US-20090317873-A1 | Design, synthesis and assembly of synthetic nucleic acids | DNA TWOPOINTO, INC. | 2009-12-24 | — | — | US | disclosed |
| US-20080300842-A1 | Design, Synthesis and Assembly of Synthetic Nucleic Acids | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-12-04 | — | — | US | disclosed |
| EP-1771579-A2 | DESIGN, SYNTHESIS AND ASSEMBLY OF SYNTHETIC NUCLEIC ACIDS | DNA TWOPOINTO INC. (US) | 2007-04-11 | — | — | EP | disclosed |
| WO-2005115102-A2 | DESIGN, SYNTHESIS AND ASSEMBLY OF SYNTHETIC NUCLEIC ACIDS | DNA TWOPOINTO, INC. (US) | 2005-12-08 | — | — | WO | disclosed |
| WO-1994001446-A2 | DERIVATIZED ORGANIC SOLID SUPPORT FOR NUCLEIC ACID SYNTHESIS | BECKMAN INSTRUMENTS, INC. (US) | 1994-01-20 | — | — | WO | disclosed |