Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1194806 | 0.85 | DGAT1 (0.41) | L3MBTL1GAAKDM4EALDH1A1NPC1 | |
| SCHEMBL26419960 | 0.84 | LMNA (0.39) | GAAGRM2LMNAPOLBKLKB1 | |
| SCHEMBL5212788 | 0.84 | LMNA (0.41) | L3MBTL1GAAKDM4EALDH1A1NPC1 | |
| SCHEMBL970933 | 0.81 | GAA (0.55) | GAAKDM4ENPC1LMNAPOLB | |
| SCHEMBL2089325 | 0.80 | KDM4E (0.50) | GAAKDM4EALDH1A1NPC1GRM2 | |
| SCHEMBL23212135 | 0.78 | PARP1 (0.56) | L3MBTL1ALDH1A1KLKB1DGAT1 | |
| SCHEMBL952140 | 0.76 | L3MBTL1 (0.50) | L3MBTL1GAAKDM4EALDH1A1NPC1 | |
| SCHEMBL20521837 | 0.76 | GAA (0.53) | GAAGRM2KLKB1DGAT1 | |
| SCHEMBL7807338 | 0.75 | IRAK4 (0.35) | L3MBTL1GAAALDH1A1LMNAPOLB | |
| SCHEMBL12486040 | 0.75 | L3MBTL1 (0.43) | L3MBTL1KDM4EALDH1A1NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2729448-B1 | COMPOUNDS FOR THE TREATMENT OF HIV | GILEAD SCIENCES INC (US) | 2015-09-09 | — | — | EP | disclosed |