Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 3/20 | 0.80 |
| ▸ | F3 | P13726 | 2/20 | 0.80 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.80 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.80 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.80 |
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | MAOB | P27338 | 2/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | MAOA | P21397 | 1/20 | 0.71 |
| ▸ | RAB9A | P51151 | 1/20 | 0.71 |
| ▸ | MMP1 | P03956 | 1/20 | 0.65 |
| ▸ | MMP2 | P08253 | 1/20 | 0.65 |
| ▸ | MMP9 | P14780 | 1/20 | 0.65 |
| ▸ | FOS | P01100 | 1/20 | 0.65 |
| ▸ | JUN | P05412 | 1/20 | 0.65 |
| ▸ | GSK3B | P49841 | 1/20 | 0.61 |
| ▸ | BACE1 | P56817 | 1/20 | 0.61 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.61 |
| ▸ | CA12 | O43570 | 3/20 | 0.59 |
| ▸ | CA1 | P00915 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28606746 | 1.00 | TYR (0.80) | TYRF3HSD11B1CYP2D6CYP2C9 | |
| SCHEMBL5598705 | 0.92 | JUN (0.74) | TYRF3HSD11B1CYP2D6CYP2C9 | |
| SCHEMBL5598702 | 0.92 | JUN (0.74) | TYRF3HSD11B1CYP2D6CYP2C9 | |
| SCHEMBL2198475 | 0.89 | TYR (1.00) | TYRF3HSD11B1CYP2D6CYP2C9 | |
| SCHEMBL2146080 | 0.89 | TYR (1.00) | TYRF3HSD11B1CYP2D6CYP2C9 | |
| SCHEMBL3580956 | 0.89 | TYR (1.00) | TYRF3HSD11B1CYP2D6CYP2C9 | |
| SCHEMBL15290855 | 0.88 | FOS (0.87) | TYRF3HSD11B1CYP2D6CYP2C9 | |
| SCHEMBL10631270 | 0.87 | TYR (0.95) | TYRF3HSD11B1CYP2D6CYP2C9 | |
| SCHEMBL4370894 | 0.87 | TYR (0.95) | TYRF3HSD11B1CYP2D6CYP2C9 | |
| SCHEMBL4371653 | 0.87 | TYR (0.95) | TYRF3HSD11B1CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9540299-B2 | MTOR-independent activator of TFEB for autophagy enhancement and uses thereof | HONG KONG BAPTIST UNIVERSITY (HK) | 2017-01-10 | — | — | US | disclosed |
| US-20160221907-A1 | MTOR-independent activator of TFEB for autophagy enhancement and uses thereof | HONG KONG BAPTIST UNIVERSITY (CN) | 2016-08-04 | — | — | US | disclosed |
| US-9351946-B2 | MTOR-independent activator of TFEB for autophagy enhancement and uses thereof | HONG KONG BAPTIST UNIVERSITY (HK) | 2016-05-31 | — | — | US | disclosed |
| US-20150250741-A1 | MTOR-independent activator of TFEB for autophagy enhancement and uses thereof | HONG KONG BAPTIST UNIVERSITY (HK) | 2015-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150250741-A1 | MTOR-independent activator of TFEB for autophagy enhancement and uses thereof | TFEB, SQSTM1, ATG7 | TYR 2186/4885F3 2784/4885HSD11B1 4798/4885 |
| US-20160221907-A1 | MTOR-independent activator of TFEB for autophagy enhancement and uses thereof | TFEB, SQSTM1, ATG7 | TYR 2186/4885F3 2784/4885HSD11B1 4798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.