Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12984042 | 0.86 | ALDH1A1 (0.49) | ALDH1A1POLBGAALMNANPC1 | |
| SCHEMBL12308190 | 0.85 | KMT2A (0.53) | ALDH1A1GAAKDM4ERAB9AMEN1 | |
| SCHEMBL3422770 | 0.84 | LMNA (0.54) | ALDH1A1GAALMNANPC1SMN1; SMN2 | |
| SCHEMBL3422768 | 0.84 | LMNA (0.54) | ALDH1A1GAALMNANPC1SMN1; SMN2 | |
| SCHEMBL30059085 | 0.84 | KDM4E (0.46) | ALDH1A1POLBGAAKDM4ERAB9A | |
| SCHEMBL28613992 | 0.83 | KMT2A (0.60) | ALDH1A1POLBGAALMNANPC1 | |
| SCHEMBL2327455 | 0.83 | CTSD (0.56) | ALDH1A1POLBGAALMNANPC1 | |
| SCHEMBL30600058 | 0.83 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2KDM4EKMT2ATDP1 | |
| SCHEMBL29104354 | 0.83 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2KDM4EKMT2ATDP1 | |
| SCHEMBL12308265 | 0.83 | FNTA (0.47) | ALDH1A1SMN1; SMN2KDM4EKMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170015644-A1 | TRICYCLIC PRODRUGS | GLACTONE PHARMA DEVELOPMENT AB (SE) | 2017-01-19 | — | — | US | disclosed |
| US-20170015644-A1 | TRICYCLIC PRODRUGS | GLACTONE PHARMA DEVELOPMENT AB (SE) | 2017-01-19 | — | — | US | disclosed |
| EP-3114114-A1 | TRICYCLIC PRODRUGS | Glactone Pharma Development AB (SE) | 2017-01-11 | — | — | EP | disclosed |
| WO-2015132396-A1 | TRICYCLIC PRODRUGS | GLACTONE PHARMA DEVELOPMENT AB (SE) | 2015-09-11 | — | — | WO | disclosed |
| WO-2015132396-A1 | TRICYCLIC PRODRUGS | GLACTONE PHARMA DEVELOPMENT AB (SE) | 2015-09-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170015644-A1 | TRICYCLIC PRODRUGS | PGLS, TK1, GGPS1 | ALDH1A1 448/4885POLB 1176/4885GAA 286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.