Sugi Predict

Sugi Predict / Compounds / SCHEMBL1708265

SCHEMBL1708265

SCHEMBL1708265

Nc1cc(F)cc(F)c1[N+](=O)[O-]

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 6/20 0.45
▸ ATM Q13315 1/20 0.45
▸ GRIN2D O15399 1/20 0.41
▸ GRIN3B O60391 1/20 0.41
▸ GRIN1 Q05586 1/20 0.41
▸ GRIN2A Q12879 1/20 0.41
▸ GRIN2B Q13224 1/20 0.41
▸ GRIN2C Q14957 1/20 0.41
▸ GRIN3A Q8TCU5 1/20 0.41
▸ ALDH1A1 P00352 7/20 0.40
▸ MAPT P10636 2/20 0.40
▸ NPC1 O15118 1/20 0.40
▸ LMNA P02545 1/20 0.40
▸ TP53 P04637 1/20 0.40
▸ HPGD P15428 1/20 0.40
▸ XBP1 P17861 1/20 0.40
▸ HTT P42858 1/20 0.40
▸ RAB9A P51151 1/20 0.40
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ TLR9 Q9NR96 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29745076 1.00 TDP1 (0.45) TDP1ATMGRIN2DGRIN3BGRIN1
SCHEMBL104470 0.86 TDP1 (0.52) TDP1ATMGRIN2DGRIN3BGRIN1
SCHEMBL28529592 0.83 TDP1 (0.45) TDP1ATMGRIN2DGRIN3BGRIN1
SCHEMBL28202994 0.81 GPR35 (0.48) TDP1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL5074280 0.79 ALDH1A1 (0.46) TDP1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL9000092 0.79 ALDH1A1 (0.40) TDP1ATMGRIN2DGRIN3BGRIN1
SCHEMBL1192809 0.79 GRIN2D (0.39) TDP1ATMGRIN2DGRIN3BGRIN1
SCHEMBL4647699 0.78 TDP1 (0.55) TDP1ATMALDH1A1MAPTHPGD
SCHEMBL12972509 0.77 GRIN2D (0.43) TDP1ATMGRIN2DGRIN3BGRIN1
SCHEMBL1680932 0.77 TTR (0.45) TDP1ATMGRIN2DGRIN3BGRIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260115174-A1 PHARMACOLOGICAL CORRECTORS OF RHODOPSIN AND USES THEREOF OCTANT INC (US) 2026-04-30 — — US disclosed
WO-2025101780-A1 PHARMACOLOGICAL CORRECTORS OF RHODOPSIN AND USES THEREOF OCTANT, INC. (US) 2025-05-15 — — WO disclosed
US-12269804-B2 Quinoxalinone compounds, compositions, methods, and kits for increasing genome editing efficiency VERTEX PHARMACEUTICALS INCORPORATED (US) 2025-04-08 — — US disclosed
US-20240368181-A1 QUINOXALINE DERIVATIVES AND USES THEREOF BLACK DIAMOND THERAPEUTICS, INC. (US) 2024-11-07 — — US disclosed
CN-114763357-B Indolopyrimidine tricyclic compound and preparation method and application thereof 中国科学院上海药物研究所 2024-06-18 — — CN disclosed
CN-111770921-B Quinoxalinone compounds, compositions, methods and kits for improving genome editing efficiency 沃泰克斯药物股份有限公司 2024-03-22 — — CN disclosed
CN-115260105-B Aromatic heterocarbamic acid compound and preparation method and application thereof 启东东岳药业有限公司 2024-01-16 — — CN disclosed
EP-4288426-A1 QUINOXALINE DERIVATIVES AND USES THEREOF Black Diamond Therapeutics, Inc. (US) 2023-12-13 — — EP disclosed
CN-117203202-A Quinoxaline derivative and use thereof 黑钻治疗公司 2023-12-08 — — CN disclosed
US-20230374015-A1 INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES KINNATE BIOPHARMA INC. 2023-11-23 — — US disclosed
EP-1702919-A1 NOVEL 2-HETEROARYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE BANYU PHARMACEUTICAL CO., LTD. (JP) 2006-09-20 — — EP disclosed
US-20060058553-A1 Novel bicyclic hydroxamates as inhibitors of histone deacetylase AXYS PHARMACEUTICALS, INC. (US) 2006-03-16 — — US disclosed
EP-1472216-A2 NOVEL BICYCLIC HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE Axys Pharmaceuticals (US) 2004-11-03 — — EP disclosed
WO-2003066579-A2 NOVEL BICYCLIC HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE AXYS PHARMACEUTICALS (US) 2003-08-14 — — WO disclosed
CN-1044473-C Tropone-substituted phenyloxazolidinone antibacterial agents FAMASIA & UPJOHN COMPANY (US) 1999-08-04 — — CN disclosed
EP-0673370-B1 TROPONE-SUBSTITUTED PHENYLOXAZOLIDINONE ANTIBACTERIAL AGENTS UPJOHN CO (US) 1998-01-07 — — EP disclosed
US-5523403-A Tropone-substituted phenyloxazolidinone antibacterial agents THE UPJOHN COMPANY (US) 1996-06-04 — — US disclosed
EP-0673370-A1 TROPONE-SUBSTITUTED PHENYLOXAZOLIDINONE ANTIBACTERIAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 1995-09-27 — — EP disclosed
CN-1092413-A The phenyloxazolidinone antibacterial agents that tropone replaces UPJOHN CO (US) 1994-09-21 — — CN disclosed
WO-1994013649-A1 TROPONE-SUBSTITUTED PHENYLOXAZOLIDINONE ANTIBACTERIAL AGENTS THE UPJOHN COMPANY (US) 1994-06-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12269804-B2 Quinoxalinone compounds, compositions, methods, and kits for increasing genome editing efficiency XRCC6, LIG1, DCK TDP1 53/4885ATM 38/4885GRIN2D 3657/4885
US-20230374015-A1 INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES FGFR1, FGFR2, FGFR3 TDP1 2063/4885ATM 484/4885GRIN2D 4213/4885
US-20260115174-A1 PHARMACOLOGICAL CORRECTORS OF RHODOPSIN AND USES THEREOF PDE6D, PDE6H, ADRA1D TDP1 1657/4885ATM 4128/4885GRIN2D 3732/4885
US-20240368181-A1 QUINOXALINE DERIVATIVES AND USES THEREOF NQO2, NQO1, GLS TDP1 1422/4885ATM 916/4885GRIN2D 2407/4885
US-20060058553-A1 Novel bicyclic hydroxamates as inhibitors of histone deacetylase HDAC1, HDAC2, HDAC11 TDP1 1101/4885ATM 3012/4885GRIN2D 1776/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.