Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.30 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1707921 | 0.84 | CD274 (0.34) | PDCD1CD274HAO1 | |
| SCHEMBL1708101 | 0.84 | RORC (0.33) | PDCD1CD274 | |
| SCHEMBL1708447 | 0.84 | CD274 (0.33) | PDCD1CD274HAO1 | |
| SCHEMBL3718036 | 0.81 | DHFR (0.31) | PDCD1CD274 | |
| SCHEMBL1707949 | 0.80 | PDCD1 (0.36) | PDCD1CD274HAO1 | |
| SCHEMBL10291778 | 0.78 | FFAR1 (0.39) | PDCD1CD274 | |
| SCHEMBL1707920 | 0.78 | FFAR1 (0.46) | — | |
| SCHEMBL1707845 | 0.78 | PDCD1 (0.33) | PDCD1CD274 | |
| SCHEMBL1708201 | 0.78 | PDCD1 (0.33) | PDCD1CD274 | |
| SCHEMBL1708462 | 0.78 | SMN1; SMN2 (0.37) | PDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |