Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | INSR | P06213 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708201 | 0.88 | PDCD1 (0.33) | PDCD1CD274MAPTKDM4EALDH1A1 | |
| SCHEMBL1708220 | 0.85 | INSR (0.35) | PDCD1CD274MAPTKDM4EALDH1A1 | |
| SCHEMBL13046592 | 0.79 | FFAR1 (0.40) | PDCD1CD274 | |
| SCHEMBL1707908 | 0.78 | CD274 (0.41) | PDCD1CD274KMT2A | |
| SCHEMBL1708219 | 0.78 | FFAR1 (0.46) | — | |
| SCHEMBL1708437 | 0.78 | PDCD1 (0.33) | PDCD1CD274 | |
| SCHEMBL1707949 | 0.77 | PDCD1 (0.36) | PDCD1CD274MAPTINSRIGF1R | |
| SCHEMBL1708101 | 0.77 | RORC (0.33) | PDCD1CD274 | |
| SCHEMBL10291553 | 0.76 | FFAR1 (0.37) | MAPTKDM4EALDH1A1KMT2ATDP1 | |
| SCHEMBL1707867 | 0.75 | ALDH1A1 (0.40) | PDCD1CD274MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |