Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | EED | O75530 | 1/20 | 0.30 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.30 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708277 | 0.89 | RORC (0.33) | RORC | |
| SCHEMBL1708296 | 0.85 | CD274 (0.34) | RORCPDCD1CD274EEDSUZ12 | |
| SCHEMBL1708437 | 0.84 | PDCD1 (0.33) | PDCD1CD274 | |
| SCHEMBL1707926 | 0.80 | RORC (0.32) | RORC | |
| SCHEMBL1708103 | 0.79 | FFAR1 (0.39) | PDCD1CD274 | |
| SCHEMBL1708294 | 0.78 | FFAR1 (0.45) | — | |
| SCHEMBL1707949 | 0.77 | PDCD1 (0.36) | PDCD1CD274 | |
| SCHEMBL1707845 | 0.77 | PDCD1 (0.33) | PDCD1CD274 | |
| SCHEMBL1708201 | 0.77 | PDCD1 (0.33) | PDCD1CD274 | |
| SCHEMBL1708462 | 0.77 | SMN1; SMN2 (0.37) | RORCPDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |