Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 5/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708208 | 0.91 | HAO1 (0.32) | PDCD1CD274POLBINSRIGF1R | |
| SCHEMBL1707908 | 0.81 | CD274 (0.41) | PDCD1CD274RAB9A | |
| SCHEMBL1708437 | 0.80 | PDCD1 (0.33) | PDCD1CD274HAO1 | |
| SCHEMBL1707867 | 0.79 | ALDH1A1 (0.40) | PDCD1CD274POLBINSRIGF1R | |
| SCHEMBL1708332 | 0.78 | ALDH1A1 (0.32) | PDCD1CD274POLBINSRIGF1R | |
| SCHEMBL1708101 | 0.77 | RORC (0.33) | PDCD1CD274 | |
| SCHEMBL1708201 | 0.77 | PDCD1 (0.33) | PDCD1CD274MAPT | |
| SCHEMBL1707845 | 0.77 | PDCD1 (0.33) | PDCD1CD274INSRIGF1RMAPT | |
| SCHEMBL1708462 | 0.77 | SMN1; SMN2 (0.37) | PDCD1CD274MAPTGAARAB9A | |
| SCHEMBL1707964 | 0.75 | INSR (0.36) | PDCD1CD274INSRIGF1RHAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |