Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 7/20 | 0.48 |
| ▸ | MAOB | P27338 | 7/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.48 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL539890 | 0.84 | LIPE (0.54) | RAB9AMEN1KMT2ANPC1MAOA | |
| SCHEMBL29950569 | 0.84 | LIPE (0.54) | RAB9AMEN1KMT2ANPC1MAOA | |
| SCHEMBL257946 | 0.84 | RAB9A (0.47) | RAB9AMEN1KMT2ANPC1ACHE | |
| SCHEMBL17912884 | 0.81 | RAB9A (0.52) | RAB9AMEN1KMT2ANPC1ACHE | |
| SCHEMBL1129280 | 0.81 | PTGES (0.50) | RAB9AMEN1KMT2ANPC1ACHE | |
| SCHEMBL12419796 | 0.80 | ENPP2 (0.48) | RAB9AMEN1KMT2ANPC1ACHE | |
| SCHEMBL19612420 | 0.80 | RAB9A (0.53) | RAB9AMEN1KMT2ANPC1ACHE | |
| SCHEMBL12419801 | 0.79 | MAOA (0.46) | RAB9ANPC1ACHEMAOAMAOB | |
| SCHEMBL4048727 | 0.79 | PTGS1 (0.46) | MEN1KMT2ALTA4HCA12CA1 | |
| SCHEMBL539019 | 0.79 | THRA (0.45) | RAB9AMEN1KMT2ANPC1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139561-B2 | Heteroaromatic compounds and their use as dopamine D1 ligands | PFIZER INC. (US) | 2015-09-22 | — | — | US | disclosed |
| US-9139561-B2 | Heteroaromatic compounds and their use as dopamine D1 ligands | PFIZER INC. (US) | 2015-09-22 | — | — | US | disclosed |