Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 2/20 | 0.46 |
| ▸ | Q9HBH1 | 1/20 | 0.44 | |
| ▸ | SSTR3 | P32745 | 1/20 | 0.42 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.41 |
| ▸ | FURIN | P09958 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23425577 | 0.83 | KLKB1 (0.45) | KLKB1PDFSSTR3CALCRLPLG | |
| SCHEMBL17424310 | 0.81 | SPHK1 (0.51) | KLKB1PDFSSTR3PLGLTA4H | |
| SCHEMBL27291531 | 0.78 | FURIN (0.49) | KLKB1PDFSSTR3CALCRLFURIN | |
| SCHEMBL25100592 | 0.78 | SIRT2 (0.42) | KLKB1PDFSSTR3MMP3SIRT2 | |
| SCHEMBL25052999 | 0.77 | SIRT2 (0.51) | SIRT2SIRT1 | |
| SCHEMBL22452312 | 0.76 | SIRT2 (0.44) | KLKB1PDFSSTR3CALCRLLTA4H | |
| SCHEMBL26283842 | 0.76 | CPB1 (0.49) | KLKB1MMP3SIRT2SIRT1 | |
| SCHEMBL16418621 | 0.76 | KLKB1 (0.49) | KLKB1PDFSSTR3CALCRLPLG | |
| SCHEMBL16854865 | 0.75 | CALCRL (0.54) | SSTR3CALCRLFURINPLGLTA4H | |
| SCHEMBL27291534 | 0.74 | FURIN (0.48) | KLKB1PDFSSTR3CALCRLFURIN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9138485-B2 | Immunoconjugates with an intracellularly-cleavable linkage | IMMUNOMEDICS, INC. (US) | 2015-09-22 | — | — | US | disclosed |