Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 5/20 | 0.51 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.47 |
| ▸ | Q9HBH1 | 1/20 | 0.47 | |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24774255 | 0.86 | LTA4H (0.49) | SPHK1KLKB1PDFLTA4HHDAC2 | |
| SCHEMBL27291531 | 0.86 | FURIN (0.49) | SPHK1KLKB1PDFCRHBPCRHR2 | |
| SCHEMBL24086378 | 0.84 | SPHK1 (0.49) | SPHK1CRHBPCRHR2HDAC3HDAC4 | |
| SCHEMBL19234733 | 0.83 | LTA4H (0.60) | SPHK1CRHBPCRHR2LTA4HSPHK2 | |
| SCHEMBL27291530 | 0.82 | FURIN (0.51) | KLKB1PDFSSTR3 | |
| SCHEMBL17090699 | 0.81 | KLKB1 (0.46) | SPHK1KLKB1PDFCRHBPCRHR2 | |
| SCHEMBL27291534 | 0.77 | FURIN (0.48) | KLKB1PDFPLGSSTR3CA1 | |
| SCHEMBL19445708 | 0.76 | KLKB1 (0.39) | SPHK1KLKB1PDFLTA4HPLG | |
| SCHEMBL21527195 | 0.76 | CA1 (0.54) | SPHK1PDFSPHK2CA1CA2 | |
| SCHEMBL12264542 | 0.76 | SIRT6 (0.43) | CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9233172-B2 | Immunoconjugates with an intracellularly-cleavable linkage | IMMUNOMEDICS, INC. (US) | 2016-01-12 | — | — | US | disclosed |