Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.62 |
| ▸ | DRD2 | P14416 | 3/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709249 | 0.87 | DRD4 (0.60) | HTR1ADRD2SIGMAR1SCN9A | |
| SCHEMBL1709242 | 0.80 | OPRL1 (0.47) | DRD2SIGMAR1SCN9A | |
| SCHEMBL6509439 | 0.79 | DRD2 (1.00) | HTR1ADRD2SIGMAR1MAPTNPSR1 | |
| SCHEMBL1709239 | 0.78 | KDM4E (0.46) | HTR1ADRD2MAPTSCN9AADRA1D | |
| SCHEMBL1709237 | 0.73 | SCN9A (0.58) | HTR1ADRD2SIGMAR1SCN9ANAMPT | |
| SCHEMBL6056974 | 0.72 | SLC6A3 (0.83) | HTR1ADRD2SIGMAR1MAPTNPSR1 | |
| SCHEMBL14407778 | 0.72 | SLC6A3 (0.83) | HTR1ADRD2SIGMAR1MAPTNPSR1 | |
| SCHEMBL7264546 | 0.72 | SLC6A3 (0.83) | HTR1ADRD2SIGMAR1MAPTNPSR1 | |
| SCHEMBL13150782 | 0.72 | SLC6A3 (0.83) | HTR1ADRD2SIGMAR1MAPTNPSR1 | |
| SCHEMBL1709241 | 0.71 | SCN9A (0.54) | DRD2SIGMAR1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |