Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 4/20 | 0.60 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709210 | 0.87 | HTR1A (0.62) | SCN9ASIGMAR1DRD2HTR1A | |
| SCHEMBL1709242 | 0.82 | OPRL1 (0.47) | SCN9ASIGMAR1DRD2DRD3 | |
| SCHEMBL1709239 | 0.80 | KDM4E (0.46) | DRD4SCN9ADRD2DRD3HTR1A | |
| SCHEMBL6031812 | 0.77 | DRD4 (1.00) | DRD4SIGMAR1DRD2DRD3HTR1A | |
| SCHEMBL1709241 | 0.73 | SCN9A (0.54) | SCN9ASIGMAR1DRD2HTR7KDM4E | |
| SCHEMBL1286796 | 0.71 | USP2 (0.49) | SCN9ASIGMAR1ALDH1A1 | |
| SCHEMBL1709237 | 0.70 | SCN9A (0.58) | SCN9ASIGMAR1HTR2ADRD2HTR1A | |
| SCHEMBL8188324 | 0.70 | SIGMAR1 (1.00) | DRD4SIGMAR1 | |
| SCHEMBL576868 | 0.70 | SIGMAR1 (1.00) | DRD4SIGMAR1 | |
| SCHEMBL2489199 | 0.70 | SIGMAR1 (1.00) | DRD4SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |