Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.46 |
| ▸ | VNN1 | O95497 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.44 |
| ▸ | LOX | P28300 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | GRK5 | P34947 | 1/20 | 0.42 |
| ▸ | PRKX | P51817 | 1/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | MLYCD | O95822 | 2/20 | 0.42 |
| ▸ | HPGDS | O60760 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17091851 | 0.83 | CDK2 (0.44) | LMNACDK2GSK3BDDR1LOXL2 | |
| SCHEMBL17092299 | 0.82 | ITK (0.46) | HPGDSDGAT2 | |
| SCHEMBL30560001 | 0.80 | SYK (0.55) | LMNAHTTSMN1; SMN2CDK2GSK3B | |
| SCHEMBL17117620 | 0.80 | SYK (0.55) | LMNAHTTSMN1; SMN2CDK2GSK3B | |
| SCHEMBL17109780 | 0.78 | PTGES (0.50) | LMNAHTTSMN1; SMN2CDK2GSK3B | |
| SCHEMBL17092324 | 0.78 | GLS (0.52) | HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL31424999 | 0.77 | LOXL2 (0.57) | CDK2GSK3BVNN1LOXL2LOX | |
| SCHEMBL25638990 | 0.77 | LOXL2 (0.57) | CDK2GSK3BVNN1LOXL2LOX | |
| SCHEMBL17091853 | 0.77 | LOXL2 (0.43) | HTTVNN1LOXL2LOXMLYCD | |
| SCHEMBL20428039 | 0.76 | PTGES (0.55) | LMNACDK2GSK3BLOXL2LOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10035790-B2 | RORγ modulators | EXELIXIS, INC. (US) | 2018-07-31 | — | — | US | disclosed |
| US-20150266856-A1 | RORGamma Modulators | EXELIXIS, INC. | 2015-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266856-A1 | RORGamma Modulators | RORB, RORA, RORC | LMNA 2685/4885HTT 4596/4885SMN1; SMN2 3767/4885 |
| US-10035790-B2 | RORγ modulators | RORB, RORA, RORC | LMNA 2906/4885HTT 4137/4885SMN1; SMN2 3896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.