Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 8/20 | 0.49 |
| ▸ | CCR8 | P51685 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709235 | 0.79 | SCN9A (0.66) | NAMPTSMN1; SMN2MEN1KMT2ASCN9A | |
| SCHEMBL9965409 | 0.67 | MEN1 (0.52) | CCR8KCNH2KCNA5ACHEBACE1 | |
| SCHEMBL1286789 | 0.66 | HPGD (0.53) | ACHEKDM4EALDH1A1HTTTSHR | |
| SCHEMBL1471644 | 0.66 | OPRM1 (0.49) | GAASMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL641275 | 0.65 | ACHE (0.69) | ACHEBACE1GAASMN1; SMN2MEN1 | |
| SCHEMBL7835963 | 0.64 | ADRA2C (0.58) | GAASMN1; SMN2MEN1KMT2APKM | |
| SCHEMBL1286799 | 0.64 | BLM (0.48) | ACHEGAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL23024412 | 0.63 | TSHR (0.52) | CCR8KCNH2GAASMN1; SMN2MEN1 | |
| SCHEMBL5394977 | 0.63 | CCR8 (1.00) | CCR8KCNH2MEN1KMT2AKDM4E | |
| SCHEMBL30529335 | 0.63 | TSHR (0.52) | CCR8KCNH2GAASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |