Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.66 |
| ▸ | NAMPT | P43490 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709233 | 0.80 | ALDH1A1 (0.51) | TSHRKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL1709232 | 0.80 | SCN9A (1.00) | SCN9ANAMPTTSHRKMT2AMEN1 | |
| SCHEMBL1709215 | 0.79 | NAMPT (0.49) | SCN9ANAMPTTSHRKMT2AMEN1 | |
| SCHEMBL5545979 | 0.69 | ALDH1A1 (0.65) | TSHRKMT2AMEN1ALDH1A1NPSR1 | |
| SCHEMBL1286789 | 0.66 | HPGD (0.53) | TSHRALDH1A1HPGDTP53 | |
| SCHEMBL1927946 | 0.66 | HPGD (1.00) | TSHRALDH1A1HPGDLMNATP53 | |
| SCHEMBL243236 | 0.66 | HPGD (1.00) | TSHRALDH1A1HPGDLMNATP53 | |
| SCHEMBL8919062 | 0.66 | HPGD (1.00) | TSHRALDH1A1HPGDLMNATP53 | |
| SCHEMBL436090 | 0.66 | HPGD (1.00) | TSHRALDH1A1HPGDLMNATP53 | |
| SCHEMBL27929296 | 0.66 | HPGD (1.00) | TSHRALDH1A1HPGDLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |