Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.59 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NPY1R | P25929 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709240 | 0.75 | SCN9A (0.60) | SCN9AALDH1A1KMT2ACCR3ATM | |
| SCHEMBL17389438 | 0.75 | SCN9A (0.48) | SCN9ALMNA | |
| SCHEMBL20567442 | 0.75 | SCN9A (0.48) | SCN9ALMNA | |
| SCHEMBL1709252 | 0.75 | SCN9A (0.56) | SCN9ALMNAKMT2ASIGMAR1 | |
| SCHEMBL1709236 | 0.74 | SCN9A (1.00) | SCN9AMAPTALDH1A1HTTKMT2A | |
| SCHEMBL1709241 | 0.72 | SCN9A (0.54) | SCN9AALDH1A1NPY1RHTR7SIGMAR1 | |
| SCHEMBL10072038 | 0.70 | SCN9A (0.53) | SCN9AALDH1A1LMNAKMT2AHTR7 | |
| SCHEMBL18298019 | 0.70 | NAMPT (0.55) | ATM | |
| SCHEMBL1709243 | 0.69 | SCN9A (0.52) | SCN9AMAPTLMNAKMT2APOLB | |
| SCHEMBL1709237 | 0.67 | SCN9A (0.58) | SCN9AHTR1ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |