Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GFER | P55789 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709240 | 0.75 | SCN9A (0.60) | SCN9AL3MBTL1GFERSIGMAR1ALDH1A1 | |
| SCHEMBL1709238 | 0.74 | SCN9A (0.59) | SCN9AMAPTPOLBSIGMAR1ALDH1A1 | |
| SCHEMBL1709252 | 0.72 | SCN9A (0.56) | SCN9ASIGMAR1MEN1KMT2ADRD2 | |
| SCHEMBL1709241 | 0.71 | SCN9A (0.54) | SCN9AL3MBTL1GFERSIGMAR1ALDH1A1 | |
| SCHEMBL1709251 | 0.70 | SCN9A (0.54) | SCN9AMAPTGFERALDH1A1KDM4E | |
| SCHEMBL10072038 | 0.69 | SCN9A (0.53) | SCN9AALDH1A1MEN1KMT2AUSP2 | |
| SCHEMBL1709249 | 0.69 | DRD4 (0.60) | SCN9ASIGMAR1DRD4ALDH1A1KDM4E | |
| SCHEMBL1709243 | 0.68 | SCN9A (0.52) | SCN9AMAPTPOLBKDM4EMEN1 | |
| SCHEMBL1286796 | 0.67 | USP2 (0.49) | SCN9AL3MBTL1POLBSIGMAR1ALDH1A1 | |
| SCHEMBL10071960 | 0.66 | SCN9A (0.49) | SCN9AMAPTALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |