Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.56 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709238 | 0.75 | SCN9A (0.59) | SCN9AKMT2ALMNASIGMAR1 | |
| SCHEMBL1709241 | 0.75 | SCN9A (0.54) | SCN9ADPP4DRD2SIGMAR1CHRNA7 | |
| SCHEMBL1709240 | 0.73 | SCN9A (0.60) | SCN9AKMT2ASIGMAR1MEN1 | |
| SCHEMBL1709236 | 0.72 | SCN9A (1.00) | SCN9AKMT2ADRD2SIGMAR1MEN1 | |
| SCHEMBL10072038 | 0.70 | SCN9A (0.53) | SCN9AKMT2ALMNATSHRCHRNA7 | |
| SCHEMBL1709243 | 0.69 | SCN9A (0.52) | SCN9AKMT2ALMNAMEN1 | |
| SCHEMBL1709237 | 0.69 | SCN9A (0.58) | SCN9ADRD2SIGMAR1 | |
| SCHEMBL1709251 | 0.66 | SCN9A (0.54) | SCN9AKMT2AMEN1 | |
| SCHEMBL1709217 | 0.66 | SCN9A (0.48) | SCN9AKMT2ALMNATSHR | |
| SCHEMBL11668124 | 0.66 | DRD2 (0.49) | KMT2ANPSR1LMNAPLA2G1BTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |