Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17101688 | 0.90 | LMNA (0.51) | HTTSMN1; SMN2LMNATP53MAPT | |
| SCHEMBL17101675 | 0.87 | MEP1B (0.52) | HTTSMN1; SMN2LMNATP53HPGD | |
| SCHEMBL17101795 | 0.87 | CXCR4 (0.58) | SMN1; SMN2CXCR4LMNANR3C2POLB | |
| SCHEMBL17101703 | 0.84 | HTT (0.65) | HTTSMN1; SMN2LMNATP53MAPT | |
| SCHEMBL17101687 | 0.82 | MEP1B (0.56) | HTTSMN1; SMN2LMNAMAPTHPGD | |
| SCHEMBL17101682 | 0.81 | LMNA (0.51) | CXCR4LMNANR3C2KMT2ATSHR | |
| SCHEMBL17101706 | 0.80 | POLB (0.54) | HTTSMN1; SMN2LMNAMAPTHPGD | |
| SCHEMBL17101827 | 0.79 | NR3C2 (0.54) | SMN1; SMN2CXCR4LMNATP53MAPT | |
| SCHEMBL17101792 | 0.78 | CA12 (0.65) | HTTSMN1; SMN2LMNATP53MAPT | |
| SCHEMBL17101699 | 0.78 | LMNA (0.47) | SMN1; SMN2LMNATP53MAPTNR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015140566-A1 | PYRAZOLO-PYRIMIDINES AS INHIBITORS OF BTK | REDX PHARMA PLC (GB) | 2015-09-24 | — | — | WO | disclosed |