Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24364091 | 0.94 | CYP2D6 (0.47) | CHRNB2CHRNA7CHRNA4L3MBTL1MEN1 | |
| SCHEMBL2240750 | 0.87 | CHRNB2 (0.40) | CHRNB2CHRNA7CHRNA4L3MBTL1MEN1 | |
| SCHEMBL2240758 | 0.87 | CHRNB2 (0.40) | CHRNB2CHRNA7CHRNA4L3MBTL1MEN1 | |
| SCHEMBL28922211 | 0.83 | PARP1 (0.37) | CHRNB2CHRNA7CHRNA4L3MBTL1MEN1 | |
| SCHEMBL2706701 | 0.82 | MEN1 (0.41) | CHRNB2CHRNA7CHRNA4L3MBTL1MEN1 | |
| SCHEMBL28789963 | 0.82 | ADRB1 (0.45) | CHRNB2CHRNA7CHRNA4L3MBTL1CYP2D6 | |
| SCHEMBL30617762 | 0.81 | CHRNB2 (0.53) | CHRNB2CHRNA7CHRNA4L3MBTL1MEN1 | |
| SCHEMBL28533942 | 0.81 | CHRNB2 (0.53) | CHRNB2CHRNA7CHRNA4L3MBTL1MEN1 | |
| SCHEMBL6178562 | 0.81 | CHRNB2 (0.53) | CHRNB2CHRNA7CHRNA4L3MBTL1MEN1 | |
| SCHEMBL29450126 | 0.81 | CHRNB2 (0.53) | CHRNB2CHRNA7CHRNA4L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-55043057-A | — | — | None | — | — | JP | disclosed |
| US-11161863-B2 | Chiral catalyst and method for asymmetric reduction of an imine | DALHOUSIE UNIVERSITY (CA) | 2021-11-02 | — | — | US | disclosed |
| US-20200255463-A1 | CHIRAL CATALYST AND METHOD FOR ASYMMETRIC REDUCTION OF AN IMINE | DALHOUSIE UNIVERSITY (CA) | 2020-08-13 | — | — | US | disclosed |
| US-20130217729-A1 | PIPERIDINE SULPHONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2013-08-22 | — | — | US | disclosed |
| US-20120238602-A1 | PIPERIDINE SULPHONAMIDE DERIVATIVES | KNUST HENNER (DE) | 2012-09-20 | — | — | US | disclosed |
| US-8202888-B2 | Piperidine sulphonamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-06-19 | — | — | US | disclosed |
| EP-2252587-B1 | PIPERIDINE SULFONAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-07-20 | — | — | EP | disclosed |
| US-20090215742-A1 | AMIDE RESORCINOL COMPOUNDS | PFIZER, INC. | 2009-08-27 | — | — | US | disclosed |
| US-20090203736-A1 | PIPERIDINE SULPHONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-13 | — | — | US | disclosed |
| WO-2008133344-A2 | PIPERIDINE DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-11-06 | — | — | WO | disclosed |
| US-20080275085-A1 | Piperidine derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-11-06 | — | — | US | disclosed |
| EP-1879863-A1 | AMIDE RESORCINOL COMPOUNDS | Pfizer, Inc. (US) | 2008-01-23 | — | — | EP | disclosed |
| EP-1778675-A1 | CHIRAL PYRROLIDINE DERIVATIVES, AND METHODS FOR PREPARING COMPOUNDS THEREOF | Cylene Pharmaceuticals, Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006117669-A1 | AMIDE RESORCINOL COMPOUNDS | PFIZER INC. (US) | 2006-11-09 | — | — | WO | disclosed |
| WO-2006015150-A1 | CHIRAL PYRROLIDINE DERIVATIVES, AND METHODS FOR PREPARING COMPOUNDS THEREOF | CYLENE PHARMACEUTICALS (US) | 2006-02-09 | — | — | WO | disclosed |
| US-20060025468-A1 | Chiral pyrrolidine derivatives, and methods for preparing compounds thereof | CYLENE PHARMACEUTICALS | 2006-02-02 | — | — | US | disclosed |
| JP-S5543057-A | PERHYDROPYRROLOIMIDAZOLE DERIVATIVE AND BACTERICIDAL AGENT FOR AGRI- AND FORTICULTURE CONTAINING THE SAME | MITSUBISHI CHEM IND LTD | 1980-03-26 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203736-A1 | PIPERIDINE SULPHONAMIDE DERIVATIVES | HCRTR2, PER2, HCRTR1 | CHRNB2 1244/4885CHRNA7 875/4885CHRNA4 683/4885 |
| US-20060025468-A1 | Chiral pyrrolidine derivatives, and methods for preparing compounds thereof | PIN1, HPD, DHPS | CHRNB2 4795/4885CHRNA7 4252/4885CHRNA4 4292/4885 |
| US-20120238602-A1 | PIPERIDINE SULPHONAMIDE DERIVATIVES | HCRTR2, PER2, HCRTR1 | CHRNB2 1244/4885CHRNA7 875/4885CHRNA4 683/4885 |
| US-20200255463-A1 | CHIRAL CATALYST AND METHOD FOR ASYMMETRIC REDUCTION OF AN IMINE | C1R, C5, C1S | CHRNB2 2141/4885CHRNA7 1917/4885CHRNA4 2235/4885 |
| US-20090215742-A1 | AMIDE RESORCINOL COMPOUNDS | HSP90AB1, HSP90AA1, HSP90AB2P | CHRNB2 4645/4885CHRNA7 4663/4885CHRNA4 4524/4885 |
| US-20080275085-A1 | Piperidine derivative and use thereof | TACR2, TACR1, PRLHR | CHRNB2 1145/4885CHRNA7 562/4885CHRNA4 571/4885 |
| US-11161863-B2 | Chiral catalyst and method for asymmetric reduction of an imine | C1R, C5, C1S | CHRNB2 2141/4885CHRNA7 1917/4885CHRNA4 2235/4885 |
| US-20130217729-A1 | PIPERIDINE SULPHONAMIDE DERIVATIVES | HCRTR2, PER2, HCRTR1 | CHRNB2 1244/4885CHRNA7 875/4885CHRNA4 683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.