Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UGT2B7 | P16662 | 1/20 | 0.50 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23256340 | 0.83 | ABCB11 (0.55) | CYP1A2TSHRAKR1C3AKR1C2 | |
| SCHEMBL23255699 | 0.83 | ABCB11 (0.55) | CYP1A2TSHRAKR1C3AKR1C2 | |
| SCHEMBL9740034 | 0.82 | UGT2B7 (0.46) | UGT2B7AOC3MMP9MEN1KMT2A | |
| SCHEMBL11672373 | 0.81 | UGT2B7 (0.61) | UGT2B7AOC3MMP9MEN1KMT2A | |
| SCHEMBL4731012 | 0.79 | UGT2B7 (0.42) | UGT2B7AOC3MMP9MEN1KMT2A | |
| SCHEMBL1702036 | 0.79 | AKR1C3 (0.47) | UGT2B7AOC3MMP9MEN1KMT2A | |
| SCHEMBL19197974 | 0.78 | UGT2B7 (0.57) | UGT2B7MMP9MEN1KMT2ACYP1A2 | |
| SCHEMBL8241125 | 0.77 | ALDH1A1 (0.42) | KMT2AADRA2AADRA2BADRA2C | |
| SCHEMBL7688541 | 0.77 | ALDH1A1 (0.42) | KMT2AADRA2AADRA2BADRA2C | |
| SCHEMBL7055482 | 0.77 | UGT2B7 (0.61) | UGT2B7AOC3MMP9MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102186476-A | Tryptophan hydroxylase inhibitors and methods of their use | LEXICON PHARMACEUTICALS INC | 2011-09-14 | — | — | CN | disclosed |
| EP-2344160-A1 | TRYPTOPHAN HYDROXYLASE INHIBITORS AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2011-07-20 | — | — | EP | disclosed |
| US-20100087433-A1 | Methods of inhibiting tryptophan hydroxylase | LEXICON PHARMACEUTICALS, INC. | 2010-04-08 | — | — | US | disclosed |
| WO-2010039957-A1 | TRYPTOPHAN HYDROXYLASE INHIBITORS AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. (US) | 2010-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087433-A1 | Methods of inhibiting tryptophan hydroxylase | TPH1, TPH2, HNMT | UGT2B7 1096/4885AOC3 409/4885MMP9 939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.