Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.51 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.51 |
| ▸ | MPL | P40238 | 4/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | AKT2 | P31751 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17188783 | 0.91 | RAB9A (0.52) | PIK3CDPIK3CAPIK3CGRAB9ANPC1 | |
| SCHEMBL13071511 | 0.80 | DPP4 (0.47) | PIK3CDPIK3CAPIK3CGPIK3CBDPP4 | |
| SCHEMBL17188722 | 0.76 | CCNT1 (0.51) | PIK3CDPIK3CANPC1DPP4MEN1 | |
| SCHEMBL17188792 | 0.74 | RAB9A (0.45) | RAB9ANPC1ALDH1A1MAPK1MEN1 | |
| SCHEMBL7988045 | 0.74 | RAB9A (0.62) | RAB9ANPC1ALDH1A1MAPK1MEN1 | |
| SCHEMBL17400523 | 0.69 | ABL1 (0.70) | MPLTRPA1TRPV4RAB9ANPC1 | |
| SCHEMBL480671 | 0.69 | TRPA1 (0.58) | MPLTRPA1TRPV4RAB9ANPC1 | |
| SCHEMBL7997452 | 0.68 | TRPV1 (0.47) | PIK3CDPIK3CAPIK3CGPIK3CBRAB9A | |
| SCHEMBL21005885 | 0.67 | MPL (0.66) | MPLTRPA1TRPV4RAB9ANPC1 | |
| SCHEMBL13071391 | 0.67 | DPP4 (0.50) | DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265606-B1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2015-10-21 | — | — | EP | disclosed |