Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CD44 | P16070 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | LDHB | P07195 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29918124 | 0.85 | ALDH1A1 (0.44) | ALDH1A1MAPK1SMN1; SMN2CYP3A4KDM4E | |
| SCHEMBL8861080 | 0.85 | KDM4E (0.40) | ALDH1A1MAPK1SMN1; SMN2CYP3A4KDM4E | |
| SCHEMBL29918082 | 0.82 | KDM4E (0.44) | ALDH1A1MAPK1SMN1; SMN2CYP3A4KDM4E | |
| SCHEMBL7952598 | 0.80 | ALDH1A1 (0.46) | ALDH1A1MAPK1SMN1; SMN2CYP3A4KDM4E | |
| SCHEMBL28700659 | 0.78 | ALDH1A1 (0.44) | ALDH1A1MAPK1SMN1; SMN2CYP3A4KDM4E | |
| SCHEMBL5472015 | 0.78 | CYP3A4 (0.45) | ALDH1A1MAPK1SMN1; SMN2CYP3A4KDM4E | |
| SCHEMBL7022036 | 0.74 | ALDH1A1 (0.40) | ALDH1A1MAPK1SMN1; SMN2CYP3A4KDM4E | |
| SCHEMBL8762020 | 0.74 | CYP3A4 (0.44) | ALDH1A1MAPK1SMN1; SMN2CYP3A4KDM4E | |
| SCHEMBL27451659 | 0.74 | CYP3A4 (0.45) | ALDH1A1MAPK1SMN1; SMN2CYP3A4KDM4E | |
| SCHEMBL30888615 | 0.72 | ALDH1A1 (0.46) | ALDH1A1MAPK1SMN1; SMN2CYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170281532-A1 | 2 SUBSTITUTED CEPHEM COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2017-10-05 | — | — | US | disclosed |
| US-20150299223-A1 | 2-SUBSTITUTED CEPHEM COMPOUNDS | GLAXO GROUP LTD (GB) | 2015-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170281532-A1 | 2 SUBSTITUTED CEPHEM COMPOUNDS | CEP170, CES2, CMBL | ALDH1A1 1437/4885MAPK1 4620/4885SMN1; SMN2 4325/4885 |
| US-20150299223-A1 | 2-SUBSTITUTED CEPHEM COMPOUNDS | CEP170, ABL1, CEPT1 | ALDH1A1 3320/4885MAPK1 3118/4885SMN1; SMN2 4571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.