Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 7/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL244194 | 0.80 | MAPK1 (0.56) | ALDH1A1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL28226595 | 0.79 | ALDH1A1 (0.42) | ALDH1A1RAB9AKMT2ANPC1MAPT | |
| SCHEMBL28227459 | 0.79 | ALDH1A1 (0.42) | ALDH1A1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL17187120 | 0.79 | MAOB (0.52) | ALDH1A1RAB9ASMN1; SMN2MAPTLMNA | |
| SCHEMBL28400665 | 0.75 | LMNA (0.65) | ALDH1A1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL29083293 | 0.72 | XDH (0.42) | RAB9ASMN1; SMN2KMT2AMEN1NPC1 | |
| SCHEMBL28248341 | 0.72 | MAPT (0.49) | ALDH1A1SMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL28227470 | 0.72 | LOXL2 (0.42) | ALDH1A1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL28395393 | 0.71 | MAPT (0.57) | ALDH1A1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7489890 | 0.71 | KDR (0.40) | ALDH1A1RAB9ASMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015159175-A1 | TROPOMYOSIN-RELATED KINASE INHIBITORS CONTAINING BOTH A 1H-PYRAZOLE AND A PYRIMIDINE MOIETY | PFIZER INC. (US) | 2015-10-22 | — | — | WO | disclosed |