Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.50 |
| ▸ | RAB9A | P51151 | 9/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28425661 | 0.86 | CYP1A2 (0.47) | MAPK1CYP1A2CYP2C19SMN1; SMN2RAB9A | |
| SCHEMBL29083293 | 0.84 | XDH (0.42) | MAPK1CYP1A2CYP2C19SMN1; SMN2RAB9A | |
| SCHEMBL28395393 | 0.83 | MAPT (0.57) | MAPK1CYP1A2CYP2C19SMN1; SMN2RAB9A | |
| SCHEMBL28284102 | 0.83 | LMNA (0.41) | MAPK1CYP1A2CYP2C19SMN1; SMN2RAB9A | |
| SCHEMBL28226658 | 0.83 | PTGS2 (0.54) | CYP1A2CYP2C19SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL28226595 | 0.82 | ALDH1A1 (0.42) | MAPK1CYP1A2CYP2C19RAB9AALDH1A1 | |
| SCHEMBL28227459 | 0.82 | ALDH1A1 (0.42) | MAPK1CYP1A2CYP2C19SMN1; SMN2RAB9A | |
| SCHEMBL537294 | 0.81 | KDM4E (0.49) | MAPK1CYP1A2CYP2C19RAB9AALDH1A1 | |
| SCHEMBL28400665 | 0.80 | LMNA (0.65) | SMN1; SMN2RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL28227470 | 0.80 | LOXL2 (0.42) | MAPK1CYP1A2CYP2C19SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115304607-B | Pyrazolopyrimidine derivative and process for preparing same | 华南农业大学 | 2023-06-27 | — | — | CN | disclosed |
| CN-115304607-A | Process for preparing pyrazolopyrimidine derivatives | 华南农业大学 | 2022-11-08 | — | — | CN | disclosed |
| CN-108203450-B | Preparation method and application of amino phosphonate containing arylpyrazole compound | 南京工业大学 | 2020-05-19 | — | — | CN | disclosed |
| CN-109575006-A | A kind of diazole pyrazole amide analog derivative and its microwave attenuation materials method and application | 中南民族大学 | 2019-04-05 | — | — | CN | disclosed |
| US-20170197939-A1 | Tropomyosin-Related Kinase Inhibitors Containing Both A 1H-Pyrazole And A Pyrimidine Moiety | PFIZER INC. (US) | 2017-07-13 | — | — | US | disclosed |
| US-20170197939-A1 | Tropomyosin-Related Kinase Inhibitors Containing Both A 1H-Pyrazole And A Pyrimidine Moiety | PFIZER INC. (US) | 2017-07-13 | — | — | US | disclosed |
| US-20170197939-A1 | Tropomyosin-Related Kinase Inhibitors Containing Both A 1H-Pyrazole And A Pyrimidine Moiety | PFIZER INC. (US) | 2017-07-13 | — | — | US | disclosed |
| EP-3140298-A1 | TROPOMYOSIN-RELATED KINASE INHIBITORS | Pfizer Inc. (US) | 2017-03-15 | — | — | EP | disclosed |
| EP-3131891-A1 | TROPOMYOSIN-RELATED KINASE INHIBITORS CONTAINING BOTH A 1H-PYRAZOLE AND A PYRIMIDINE MOIETY | Pfizer Inc. (US) | 2017-02-22 | — | — | EP | disclosed |
| US-9328096-B2 | Tropomyosin-related kinase inhibitors | PFIZER INC. (US) | 2016-05-03 | — | — | US | disclosed |
| US-20150322043-A1 | TROPOMYOSIN-RELATED KINASE INHIBITORS | PFIZER (US) | 2015-11-12 | — | — | US | disclosed |
| US-20150322043-A1 | TROPOMYOSIN-RELATED KINASE INHIBITORS | PFIZER (US) | 2015-11-12 | — | — | US | disclosed |
| WO-2015159175-A1 | TROPOMYOSIN-RELATED KINASE INHIBITORS CONTAINING BOTH A 1H-PYRAZOLE AND A PYRIMIDINE MOIETY | PFIZER INC. (US) | 2015-10-22 | — | — | WO | disclosed |
| WO-2015159175-A1 | TROPOMYOSIN-RELATED KINASE INHIBITORS CONTAINING BOTH A 1H-PYRAZOLE AND A PYRIMIDINE MOIETY | PFIZER INC. (US) | 2015-10-22 | — | — | WO | disclosed |
| EP-2443093-B1 | PROCESS FOR THE PREPARATION OF PYRAZOLE DERIVATIVES | BASF SE (DE) | 2013-07-03 | — | — | EP | disclosed |
| US-8288563-B2 | Process for the preparation of pyrazole derivatives | BASF SE (DE) | 2012-10-16 | — | — | US | disclosed |
| EP-2443093-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE DERIVATIVES | BASF SE (DE) | 2012-04-25 | — | — | EP | disclosed |
| US-20120004421-A1 | Process for the preparation of pyrazole derivatives | BASF SE (DE) | 2012-01-05 | — | — | US | disclosed |
| WO-2010105969-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE DERIVATIVES | BASF SE (DE) | 2010-09-23 | — | — | WO | disclosed |
| CN-101675051-A | Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors | WYETH CORP | 2010-03-17 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150322043-A1 | TROPOMYOSIN-RELATED KINASE INHIBITORS | TPM3, MUSK, TPM4 | MAPK1 379/4885CYP1A2 3621/4885CYP2C19 4074/4885 |
| US-20120004421-A1 | Process for the preparation of pyrazole derivatives | CBR3, CBR1, C1S | MAPK1 782/4885CYP1A2 130/4885CYP2C19 251/4885 |
| US-20170197939-A1 | Tropomyosin-Related Kinase Inhibitors Containing Both A 1H-Pyrazole And A Pyrimidine Moiety | TPM3, MUSK, TPM4 | MAPK1 158/4885CYP1A2 2252/4885CYP2C19 2361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.