Sugi Predict

Sugi Predict / Compounds / SCHEMBL17201734

SCHEMBL17201734

SCHEMBL17201734

COc1cc(/C=C/c2cc(O)cc(OC)c2CC=C(C)C)ccc1O

nearest known ligand 0.65

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ TTR P02766 1/20 0.58
▸ CYP19A1 P11511 4/20 0.55
▸ PTGS2 P35354 3/20 0.55
▸ ALOX5 P09917 3/20 0.55
▸ PTGS1 P23219 1/20 0.52
▸ APP P05067 5/20 0.51
▸ OPRD1 P41143 1/20 0.50
▸ NFE2L2 Q16236 1/20 0.50
▸ TYR P14679 1/20 0.49
▸ PTGES O14684 1/20 0.48
▸ MAOA P21397 1/20 0.48
▸ MAOB P27338 1/20 0.48
▸ MAPT P10636 2/20 0.47
▸ BACE1 P56817 1/20 0.47
▸ CYP2D6 P10635 1/20 0.47
▸ CYP2C9 P11712 1/20 0.47
▸ TSHR P16473 1/20 0.47
▸ CYP2C19 P33261 1/20 0.47
▸ HSD17B10 Q99714 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17201735 1.00 TTR (0.58) TTRCYP19A1PTGS2ALOX5PTGS1
SCHEMBL30279751 1.00 TTR (0.58) TTRCYP19A1PTGS2ALOX5PTGS1
SCHEMBL17201745 0.95 TTR (0.58) TTRCYP19A1PTGS2ALOX5PTGS1
SCHEMBL13824960 0.95 TTR (0.58) TTRCYP19A1PTGS2ALOX5PTGS1
SCHEMBL17208338 0.93 PTGES (0.55) TTRCYP19A1PTGS2ALOX5PTGS1
SCHEMBL17201751 0.93 CYP19A1 (0.58) TTRCYP19A1PTGS2ALOX5PTGS1
SCHEMBL17201753 0.93 CYP19A1 (0.58) TTRCYP19A1PTGS2ALOX5PTGS1
SCHEMBL29987008 0.93 CYP19A1 (0.58) TTRCYP19A1PTGS2ALOX5PTGS1
SCHEMBL23580837 0.92 ABL1 (0.54) TTRCYP19A1PTGS2ALOX5PTGS1
SCHEMBL25261291 0.92 TTR (0.52) TTRCYP19A1PTGS2ALOX5PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230159421-A1 SUBSTITUTED HYDROXYSTILBENE COMPOUNDS AND DERIVATIVES SYNTHESIS AND USES THEREOF Kynan Duke IP, LLC (US) 2023-05-25 — — US disclosed
US-11634375-B2 Prenylated hydroxystilbenes Kynan Duke IP, LLC (US) 2023-04-25 — — US disclosed
CN-115485259-A Substituted hydroxystilbene compounds and derivatives, synthesis and use thereof 凯楠公爵IP有限责任公司 2022-12-16 — — CN disclosed
US-20220380285-A1 PRENYLATED HYDROXYSTILBENES Kynan Duke IP, LLC (US) 2022-12-01 — — US disclosed
US-11352310-B2 Prenylated hydroxystilbenes Kynan Duke IP, LLC (US) 2022-06-07 — — US disclosed
US-11352310-B2 Prenylated hydroxystilbenes Kynan Duke IP, LLC (US) 2022-06-07 — — US disclosed
EP-2709975-B1 PRENYLATED HYDROXYSTILBENES KYNAN DUKE IP LLC (US) 2022-01-12 — — EP disclosed
EP-2709975-B1 PRENYLATED HYDROXYSTILBENES KYNAN DUKE IP LLC (US) 2022-01-12 — — EP disclosed
WO-2021127743-A1 SUBSTITUTED HYDROXYSTILBENE COMPOUNDS AND DERIVATIVES SYNTHESIS AND USES THEREOF Kynan Duke IP, LLC (US) 2021-07-01 — — WO disclosed
US-20200331833-A1 PRENYLATED HYDROXYSTILBENES THE UNIVERSITY OF SYDNEY (AU) 2020-10-22 — — US disclosed
US-20200331833-A1 PRENYLATED HYDROXYSTILBENES THE UNIVERSITY OF SYDNEY (AU) 2020-10-22 — — US disclosed
CN-107266297-B Prenylated hydroxystilbenes, pharmaceutical compositions containing the same, use and preparation method thereof 悉尼大学 2020-10-16 — — CN disclosed
US-10696615-B2 Prenylated hydroxystilbenes THE UNIVERSITY OF SYDNEY (AU) 2020-06-30 — — US disclosed
US-10696615-B2 Prenylated hydroxystilbenes THE UNIVERSITY OF SYDNEY (AU) 2020-06-30 — — US disclosed
US-20190194105-A1 PRENYLATED HYDROXYSTILBENES THE UNIVERSITY OF SYDNEY (AU) 2019-06-27 — — US disclosed
US-20190194105-A1 PRENYLATED HYDROXYSTILBENES THE UNIVERSITY OF SYDNEY (AU) 2019-06-27 — — US disclosed
US-10196335-B2 Prenylated hydroxystilbenes THE UNIVERSITY OF SYDNEY (AU) 2019-02-05 — — US disclosed
US-10196335-B2 Prenylated hydroxystilbenes THE UNIVERSITY OF SYDNEY (AU) 2019-02-05 — — US disclosed
US-20150307429-A1 PRENYLATED HYDROXYSTILBENES Kynan Duke IP, LLC 2015-10-29 — — US disclosed
US-20150307429-A1 PRENYLATED HYDROXYSTILBENES Kynan Duke IP, LLC 2015-10-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10196335-B2 Prenylated hydroxystilbenes HMGB2, CYP51A1, CYP8B1 TTR 741/4885CYP19A1 212/4885PTGS2 324/4885
US-20200331833-A1 PRENYLATED HYDROXYSTILBENES HSD11B1, HSD3B1, CYP8B1 TTR 1499/4885CYP19A1 64/4885PTGS2 1767/4885
US-20220380285-A1 PRENYLATED HYDROXYSTILBENES HSD11B1, HSD3B1, CYP8B1 TTR 1499/4885CYP19A1 64/4885PTGS2 1767/4885
US-20150307429-A1 PRENYLATED HYDROXYSTILBENES HMGB2, CYP51A1, CYP8B1 TTR 741/4885CYP19A1 212/4885PTGS2 324/4885
US-10696615-B2 Prenylated hydroxystilbenes HSD11B1, CYP8B1, NR1H2 TTR 2048/4885CYP19A1 79/4885PTGS2 807/4885
US-11352310-B2 Prenylated hydroxystilbenes HSD11B1, HSD3B1, CYP8B1 TTR 1499/4885CYP19A1 64/4885PTGS2 1767/4885
US-20230159421-A1 SUBSTITUTED HYDROXYSTILBENE COMPOUNDS AND DERIVATIVES SYNTHESIS AND USES THEREOF CYP8B1, HSD11B1, HSD11B2 TTR 2074/4885CYP19A1 300/4885PTGS2 213/4885
US-20190194105-A1 PRENYLATED HYDROXYSTILBENES HSD11B1, CYP8B1, NR1H2 TTR 2048/4885CYP19A1 79/4885PTGS2 807/4885
US-11634375-B2 Prenylated hydroxystilbenes HCLS1, IWS1, UTS2R TTR 4316/4885CYP19A1 1298/4885PTGS2 1005/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.