SCHEMBL1720274

SCHEMBL1720274

CC1(c2ccc(-c3ccccc3)cc2)CC2C=CC1C2

nearest known ligand 0.37

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
SLC6A2 P23975 4/20 0.35
CHRNA1 P02708 1/20 0.35
CHRNG P07510 1/20 0.35
CHRNB1 P11230 1/20 0.35
CHRNB2 P17787 1/20 0.35
CHRNB4 P30926 1/20 0.35
CHRNA3 P32297 1/20 0.35
CHRNA4 P43681 1/20 0.35
CHRND Q07001 1/20 0.35
KDM1A O60341 5/20 0.34
MAOA P21397 1/20 0.34
SLC6A4 P31645 3/20 0.33
SLC6A3 Q01959 3/20 0.33
MAOB P27338 2/20 0.33
LPL P06858 1/20 0.31
LIPG Q9Y5X9 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL231895 0.90 MAOA (0.41) KDM1AMAOAMAOB
SCHEMBL6528313 0.90 MAOA (0.41) KDM1AMAOAMAOB
SCHEMBL4243945 0.80 MAOA (0.38) SLC6A2CHRNA1CHRNGCHRNB1CHRNB2
SCHEMBL1720397 0.78 SLC6A4 (0.39) SLC6A2KDM1ASLC6A4SLC6A3
SCHEMBL14667575 0.77 MAOB (0.44) CHRNA1CHRNGCHRNB1CHRNB2CHRNB4
SCHEMBL2896199 0.72 PDCD1 (0.41) NPC1RAB9A
SCHEMBL1733040 0.71 HTR2A (0.36) KDM1A
SCHEMBL1733173 0.71 TAAR1 (0.35) KDM1ASLC6A4
SCHEMBL1733751 0.71 BACE1 (0.34)
SCHEMBL4103952 0.69 KMT2A (0.43) NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1623967-B1 NORBORNENE DERIVATIVE, NORBORNENE POLYMER PRODUCED BY RING-OPENING (CO)POLYMERIZATION, AND PROCESS FOR PRODUCING THE POLYMER BY RING-OPENING (CO)POLYMERIZATION JSR CORP (JP) 2012-01-18 EP disclosed
US-7759437-B2 Norbornene derivative, norbornene polymer produced by ring-opening (co)polymerization, and process for producing the polymer by ring-opening (co)polymerization JSR CORPORATION (JP) 2010-07-20 US disclosed
US-7646457-B2 Liquid crystal display device FUJIFILM CORPORATION (JP) 2010-01-12 US disclosed
US-20090247798-A1 NORBORNENE DERIVATIVE, NORBORNENE POLYMER PRODUCED BY RING-OPENING (CO)POLYMERIZATION, AND PROCESS FOR PRODUCING THE POLYMER BY RING-OPENING (CO)POLYMERIZATION JSR CORPORATION (JP) 2009-10-01 US disclosed
US-20090209705-A1 THERMOPLASTIC RESIN COMPOSITION, OPTICAL FILM AND RETARDATION FILM JSR CORPORATION (JP) 2009-08-20 US disclosed
US-7541411-B2 Norbornene derivative, norbornene polymer produced by ring-opening (co)polymerization, and process for producing the polymer by ring-opening (co)polymerization JSR CORPORATION (JP) 2009-06-02 US disclosed
US-20080177002-A1 Thermoplastic Resin Composition, Optical Film, And Process For Producing Film JSR CORPORATION (JP) 2008-07-24 US disclosed
US-20080095955-A1 Thermoplastic Resin Composition and Optical Films Made Therefrom JSR CORPORATION (JP) 2008-04-24 US disclosed
US-20070282077-A1 Thermoplastic Resin Composition, Optical Film And Oriented Film JSR CORPORATION (JP) 2007-12-06 US disclosed
EP-1847567-A1 THERMOPLASTIC RESIN COMPOSITION, OPTICAL FILM AND ORIENTED FILM JSR Corporation (JP) 2007-10-24 EP disclosed
EP-1795559-A1 THERMOPLASTIC RESIN COMPOSITION, OPTICAL FILM AND RETARDATION FILM JSR Corporation (JP) 2007-06-13 EP disclosed
US-20070112158-A1 Novel (co)polymer, process for producing the same, and process for producing carboxylated (co)polymer JSR CORPORATION (JP) 2007-05-17 US disclosed
US-20070065747-A1 Norbornene derivative, norbornene polymer produced by ring-opening (co)polymerization, and process for producing the polymer by ring-opening (co)polymerization JSR CORPORATION (JP) 2007-03-22 US disclosed
US-7101498-B2 Thermoplastic norbornene resin based optical film JSR CORPORATION (JP) 2006-09-05 US disclosed
EP-1623967-A1 NORBORNENE DERIVATIVE, NORBORNENE POLYMER PRODUCED BY RING-OPENING (CO)POLYMERIZATION, AND PROCESS FOR PRODUCING THE POLYMER BY RING-OPENING (CO)POLYMERIZATION JSR Corporation (JP) 2006-02-08 EP disclosed
US-20040242824-A1 NORBORNENE DERIVATIVE AND NORBORNENE POLYMER OBTAINED THEREFROM THROUGH RING OPENING POLYMERIZATION JSR CORPORATION (JP) 2004-12-02 US disclosed
US-20040242823-A1 Thermoplastic norbornene resin based optical film JSR CORPORATION (JP) 2004-12-02 US disclosed
EP-1459107-A2 THERMOPLASTIC NORBORNENE RESIN BASED OPTICAL FILM JSR Corporation (JP) 2004-09-22 EP disclosed
EP-1435350-A1 NORBORNENE DERIVATIVE AND NORBORNENE POLYMER OBTAINED THEREFROM THROUGH RING-OPENING POLYMERIZATION JSR Corporation (JP) 2004-07-07 EP disclosed
WO-2003056365-A2 THERMOPLASTIC NORBORNENE RESIN BASED OPTICAL FILM JSR CORPORATION (JP) 2003-07-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090247798-A1 NORBORNENE DERIVATIVE, NORBORNENE POLYMER PRODUCED BY RING-OPENING (CO)POLYMERIZATION, AND PROCESS FOR PRODUCING THE POLYMER BY RING-OPENING (CO)POLYMERIZATION COASY, SQLE, CYP51A1 NPC1 1621/4885RAB9A 3587/4885SLC6A2 3736/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.