Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 5/20 | 0.33 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1694252 | 0.80 | CYP1A2 (0.37) | FPR2SCN9ACYP1A2CYP3A4HTR2C | |
| SCHEMBL793765 | 0.74 | ALDH1A1 (0.45) | CYP1A2CYP3A4HTR2BHDAC3 | |
| SCHEMBL1720288 | 0.70 | P2RY12 (0.39) | SCN9ACYP1A2CYP3A4HTR2CKIT | |
| SCHEMBL655041 | 0.66 | USP2 (0.35) | FPR2SCN9ACYP1A2CYP3A4KIT | |
| SCHEMBL798319 | 0.63 | CHEK1 (0.46) | CYP1A2CYP3A4HTR2CCHEK1 | |
| SCHEMBL12467234 | 0.63 | CHEK1 (0.39) | FPR2SCN9ACHEK1CDK2AP1HDAC3 | |
| SCHEMBL1693574 | 0.63 | FPR2 (0.39) | FPR2SCN9ACHEK1CDK2AP1 | |
| SCHEMBL653761 | 0.61 | HRH4 (0.41) | FPR2SCN9ACHEK1 | |
| SCHEMBL795138 | 0.61 | FPR2 (0.36) | FPR2SCN9ACHEK1KIT | |
| SCHEMBL798487 | 0.60 | PRKCI (0.50) | CYP1A2CYP3A4HTR2CHTR2BCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2405973-A2 | THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010103130-A2 | NOVEL BICYCLIC HETEROCYCLES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D (BE) | 2010-09-16 | — | — | WO | disclosed |