Sugi Predict

Sugi Predict / Compounds / SCHEMBL17205447

SCHEMBL17205447

SCHEMBL17205447

NC(=O)[C@@H]1CCCC[C@H]1C(N)=O

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ EPHX1 P07099 4/20 0.67
▸ GRM4 Q14833 1/20 0.47
▸ PSEN1 P49768 3/20 0.42
▸ PSEN2 P49810 3/20 0.42
▸ APH1B Q8WW43 3/20 0.42
▸ NCSTN Q92542 3/20 0.42
▸ APH1A Q96BI3 3/20 0.42
▸ PSENEN Q9NZ42 3/20 0.42
▸ ALDH1A1 P00352 1/20 0.40
▸ LMNA P02545 1/20 0.40
▸ CES2 O00748 1/20 0.38
▸ CES1 P23141 1/20 0.38
▸ ALOX5 P09917 2/20 0.37
▸ KDM4E B2RXH2 1/20 0.37
▸ MAPT P10636 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ ATM Q13315 1/20 0.37
▸ CYP2D6 P10635 1/20 0.37
▸ GLI1 P08151 1/20 0.37
▸ NOS2 P35228 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1570434 1.00 EPHX1 (0.67) EPHX1GRM4PSEN1PSEN2APH1B
SCHEMBL13557474 1.00 EPHX1 (0.67) EPHX1GRM4PSEN1PSEN2APH1B
SCHEMBL9800227 1.00 EPHX1 (0.67) EPHX1GRM4PSEN1PSEN2APH1B
SCHEMBL9800070 1.00 EPHX1 (0.67) EPHX1GRM4PSEN1PSEN2APH1B
SCHEMBL2343227 0.93 EPHX1 (0.59) EPHX1GRM4PSEN1PSEN2APH1B
SCHEMBL7362431 0.93 EPHX1 (0.59) EPHX1GRM4PSEN1PSEN2APH1B
SCHEMBL7818915 0.89 EPHX1 (0.56) EPHX1GRM4ALDH1A1LMNAKMT2A
SCHEMBL17846562 0.89 EPHX1 (0.56) EPHX1GRM4PSEN1PSEN2APH1B
SCHEMBL7815469 0.89 EPHX1 (0.56) EPHX1GRM4ALDH1A1LMNAKMT2A
SCHEMBL7815466 0.89 EPHX1 (0.56) EPHX1GRM4ALDH1A1LMNAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4613745-A2 PROCESS FOR PREPARING A COT INHIBITOR COMPOUND Gilead Sciences, Inc. (US) 2025-09-10 — — EP disclosed
CN-117050030-B Pd detection method2+Fluorescent probe of (2), preparation method and application thereof 福建省金皇环保科技有限公司 2025-07-25 — — CN disclosed
US-12365666-B2 Process for preparing a Cot inhibitor compound GILEAD SCIENCES, INC. (US) 2025-07-22 — — US disclosed
EP-4126862-B1 PROCESS FOR PREPARING A COT INHIBITOR COMPOUND GILEAD SCIENCES INC (US) 2025-05-21 — — EP disclosed
US-20240199579-A1 PROCESS FOR PREPARING A COT INHIBITOR COMPOUND GILEAD SCIENCES, INC. 2024-06-20 — — US disclosed
EP-3733667-B1 HETEROCYCLIC COMPOUNDS AND NOXIOUS ARTHROPOD CONTROL AGENT CONTAINING SAME SUMITOMO CHEMICAL CO (JP) 2024-06-12 — — EP disclosed
US-11845737-B2 Process for preparing a Cot inhibitor compound GILEAD SCIENCES, INC. (US) 2023-12-19 — — US disclosed
US-11690378-B2 Substituted pyridines as noxious arthropod control agents SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2023-07-04 — — US disclosed
EP-4126862-A1 PROCESS FOR PREPARING A COT INHIBITOR COMPOUND GILEAD SCIENCES, INC. (US) 2023-02-08 — — EP disclosed
US-20220380340-A1 PROCESS FOR PREPARING A COT INHIBITOR COMPOUND GILEAD SCIENCES, INC. 2022-12-01 — — US disclosed
WO-2021202688-A1 PROCESS FOR PREPARING A COT INHIBITOR COMPOUND GILEAD SCIENCES, INC. (US) 2021-10-07 — — WO disclosed
US-20210059255-A1 HETEROCYCLIC COMPOUNDS AND NOXIOUS ARTHROPOD CONTROL AGENT CONTAINING SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2021-03-04 — — US disclosed
EP-3733667-A1 HETEROCYCLIC COMPOUNDS AND NOXIOUS ARTHROPOD CONTROL AGENT CONTAINING SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2020-11-04 — — EP disclosed
EP-3357918-A1 NOVEL PYRIDINE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2018-08-08 — — EP disclosed
US-10030483-B2 Carbon dioxide and hydrocarbon assisted enhanced oil recovery GENERAL ELECTRIC COMPANY (US) 2018-07-24 — — US disclosed
EP-2928881-B1 NOVEL PYRIDINE DERIVATIVES HOFFMANN LA ROCHE (CH) 2018-03-14 — — EP disclosed
US-20170114269-A1 CARBON DIOXIDE AND HYDROCARBON ASSISTED ENHANCED OIL RECOVERY BAKER HUGHES, A GE COMPANY, LLC 2017-04-27 — — US disclosed
US-9522886-B2 Pyridine derivatives HOFFMANN-LA ROCHE INC. (US) 2016-12-20 — — US disclosed
US-20150307452-A1 NOVEL PYRIDINE DERIVATIVES HOFFMANN-LA ROCHE INC. (US) 2015-10-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11690378-B2 Substituted pyridines as noxious arthropod control agents COX6C, C5, COX6B1 EPHX1 1355/4885GRM4 1601/4885PSEN1 4289/4885
US-11845737-B2 Process for preparing a Cot inhibitor compound TPO, TFPI, TFPI2 EPHX1 1546/4885GRM4 4499/4885PSEN1 2077/4885
US-20220380340-A1 PROCESS FOR PREPARING A COT INHIBITOR COMPOUND TPO, TFPI, TFPI2 EPHX1 1546/4885GRM4 4499/4885PSEN1 2077/4885
US-20150307452-A1 NOVEL PYRIDINE DERIVATIVES NDUFS6, NDUFS3, NDUFV2 EPHX1 1085/4885GRM4 1307/4885PSEN1 1647/4885
US-20210059255-A1 HETEROCYCLIC COMPOUNDS AND NOXIOUS ARTHROPOD CONTROL AGENT CONTAINING SAME C5, COX6C, C3AR1 EPHX1 1276/4885GRM4 1655/4885PSEN1 4477/4885
US-20240199579-A1 PROCESS FOR PREPARING A COT INHIBITOR COMPOUND TPO, TFPI, TFPI2 EPHX1 1546/4885GRM4 4499/4885PSEN1 2077/4885
US-12365666-B2 Process for preparing a Cot inhibitor compound TPO, TFPI, TFPI2 EPHX1 1546/4885GRM4 4499/4885PSEN1 2077/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.