Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.76 |
| ▸ | RAB9A | P51151 | 1/20 | 0.76 |
| ▸ | LMNA | P02545 | 4/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | PKM | P14618 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12977184 | 0.86 | LMNA (0.67) | NPC1RAB9ALMNAALDH1A1PKM | |
| SCHEMBL2704288 | 0.85 | LMNA (0.79) | RAB9ALMNAALDH1A1PKMPOLB | |
| SCHEMBL15480560 | 0.85 | NPC1 (0.75) | NPC1RAB9ALMNAHPGDALDH1A1 | |
| SCHEMBL16615636 | 0.83 | CRHBP (0.73) | NPC1RAB9ALMNAALDH1A1PKM | |
| SCHEMBL17947677 | 0.82 | ALDH1A1 (1.00) | NPC1RAB9ALMNAALDH1A1PKM | |
| SCHEMBL27811894 | 0.81 | PKM (0.67) | RAB9ALMNAALDH1A1PKMPOLB | |
| SCHEMBL10093052 | 0.80 | POLB (0.62) | NPC1RAB9ALMNAHPGDALDH1A1 | |
| SCHEMBL9864972 | 0.80 | NPC1 (0.67) | NPC1RAB9ALMNAHPGDALDH1A1 | |
| SCHEMBL16615805 | 0.79 | ALDH1A1 (0.68) | NPC1RAB9ALMNAHPGDALDH1A1 | |
| SCHEMBL15155035 | 0.79 | POLB (0.61) | NPC1RAB9ALMNAPOLBUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344456-A1 | NOVEL POTASSIUM CHANNEL BLOCKER | Xention Limited (GB) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010023445-A1 | NOVEL POTASSIUM CHANNEL BLOCKER | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | disclosed |