Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 17/20 | 0.67 |
| ▸ | MTNR1B | P49286 | 17/20 | 0.67 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL124170 | 0.86 | MTNR1A (0.65) | MTNR1AMTNR1BDRD2HTR2ADRD3 | |
| SCHEMBL125753 | 0.82 | MTNR1B (0.66) | MTNR1AMTNR1BDRD2HTR2ADRD3 | |
| SCHEMBL172456 | 0.81 | MTNR1B (0.60) | MTNR1AMTNR1B | |
| SCHEMBL126994 | 0.80 | MTNR1A (1.00) | MTNR1AMTNR1B | |
| SCHEMBL172381 | 0.78 | MTNR1B (0.62) | MTNR1AMTNR1B | |
| SCHEMBL172150 | 0.78 | MTNR1B (0.63) | MTNR1AMTNR1BDRD2HTR2ADRD3 | |
| SCHEMBL126757 | 0.78 | MTNR1A (0.67) | MTNR1AMTNR1BHTR2A | |
| SCHEMBL124834 | 0.77 | MTNR1A (0.60) | MTNR1AMTNR1BDRD2HTR2ADRD3 | |
| SCHEMBL123962 | 0.77 | MTNR1B (1.00) | MTNR1AMTNR1B | |
| SCHEMBL172491 | 0.75 | MTNR1A (0.52) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2100895-B1 | TRICYCLIC COMPOUND AND MEDICAL USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2012-03-07 | — | — | EP | disclosed |