Sugi Predict

Sugi Predict / Compounds / SCHEMBL1725892

SCHEMBL1725892

SCHEMBL1725892

N#Cc1cnc(Cl)c(F)c1

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ HTT P42858 1/20 0.41
▸ KHK P50053 1/20 0.39
▸ MET P08581 1/20 0.38
▸ GRM5 P41594 5/20 0.38
▸ CYP11B2 P19099 2/20 0.38
▸ ALDH1A1 P00352 2/20 0.38
▸ KDM4E B2RXH2 1/20 0.38
▸ LMNA P02545 1/20 0.38
▸ GAA P10253 1/20 0.38
▸ L3MBTL1 Q9Y468 1/20 0.38
▸ CYP11B1 P15538 1/20 0.38
▸ CYP1A2 P05177 1/20 0.37
▸ NPSR1 Q6W5P4 1/20 0.37
▸ TDP1 Q9NUW8 1/20 0.37
▸ EGLN2 Q96KS0 5/20 0.36
▸ BACE1 P56817 1/20 0.34
▸ HPGDS O60760 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29637510 1.00 HTT (0.41) HTTKHKMETGRM5CYP11B2
SCHEMBL231937 0.78 TDP1 (0.44) HTTGRM5CYP11B2ALDH1A1KDM4E
SCHEMBL8024343 0.78 HTT (0.44) HTTMETGRM5CYP11B2ALDH1A1
SCHEMBL31221920 0.78 TDP1 (0.44) HTTGRM5CYP11B2ALDH1A1KDM4E
SCHEMBL15900420 0.78 BACE1 (0.37) HTTKHKMETGRM5CYP11B2
SCHEMBL7216099 0.77 ALDH1A1 (0.55) HTTKHKCYP11B2ALDH1A1KDM4E
SCHEMBL30681150 0.77 ALDH1A1 (0.55) HTTKHKCYP11B2ALDH1A1KDM4E
SCHEMBL12254186 0.76 EGLN1 (0.37) GRM5BACE1
SCHEMBL2896194 0.75 HTT (0.41) HTTGRM5ALDH1A1KDM4ELMNA
SCHEMBL2530805 0.75 S100A9 (0.46) HTTGRM5ALDH1A1KDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260078119-A1 DEGRADER COMPOUNDS AND USES THEREOF BRISTOL MYERS SQUIBB CO (US) 2026-03-19 — — US disclosed
US-20260055094-A1 FXR (NR1H4) MODULATING COMPOUNDS GILEAD SCIENCES INC (US) 2026-02-26 — — US disclosed
EP-4688771-A1 NOVEL FAK DEGRADER COMPOUNDS AND USES THEREOF Bristol-Myers Squibb Company (US) 2026-02-11 — — EP disclosed
US-12358903-B2 FXR (NR1H4) modulating compounds GILEAD SCIENCES, INC. (US) 2025-07-15 — — US disclosed
CN-114423758-B Antibacterial compounds 爱尔兰詹森科学公司 2025-05-27 — — CN disclosed
US-20240199611-A1 ANTIBACTERIAL COMPOUNDS Janssen Sciences Ireland Unlimited Company (IE) 2024-06-20 — — US disclosed
US-20240199651-A1 ANTIBACTERIAL COMPOUNDS Janssen Sciences Ireland Unlimited Company (IE) 2024-06-20 — — US disclosed
US-20240182495-A1 ANTIBACTERIAL COMPOUNDS Janssen Sciences Ireland Unlimited Company (IE) 2024-06-06 — — US disclosed
CN-117580843-A Antibacterial compounds 爱尔兰詹森科学公司 2024-02-20 — — CN disclosed
EP-4028399-B1 ANTIBACTERIAL COMPOUNDS JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) 2024-02-14 — — EP disclosed
US-20140364433-A1 SUBSTITUTED PROLINES / PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2014-12-11 — — US disclosed
US-8791142-B2 Oxazole pyridine derivatives useful as S1P1 receptor agonists MERCK SERONO S.A. (CH) 2014-07-29 — — US disclosed
US-20140080808-A1 TETRAHYDROTHIAZEPINE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-03-20 — — US disclosed
EP-2700643-A1 TETRAHYDROTHIAZEPINE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-02-26 — — EP disclosed
CN-103282352-A Benzamides and nicotinamides as syk modulators PORTOLA PHARM INC 2013-09-04 — — CN disclosed
EP-2403849-A1 OXAZOLE PYRIDINE DERIVATIVES USEFUL AS S1P1 RECEPTOR AGONISTS Merck Serono S.A. (CH) 2012-01-11 — — EP disclosed
US-20110306636-A1 OXAZOLE PYRIDINE DERIVATIVES USEFUL AS S1P1 RECEPTOR AGONISTS MERCK SERONO SA (CH) 2011-12-15 — — US disclosed
WO-2010100142-A1 OXAZOLE PYRIDINE DERIVATIVES USEFUL AS S1P1 RECEPTOR AGONISTS MERCK SERONO S.A. (CH) 2010-09-10 — — WO disclosed
CN-1308309-C Process for preparing beta-ketoester compound LG LIFE SCIENCES LTD (KR) 2007-04-04 — — CN disclosed
CN-1301262-A Novel herbicide NOVARTIS AG (CH) 2001-06-27 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140364433-A1 SUBSTITUTED PROLINES / PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS HCRTR2, HCRTR1, OPRL1 HTT 103/4885KHK 4671/4885MET 595/4885
US-20240199651-A1 ANTIBACTERIAL COMPOUNDS FDPS, MT-ND4, NDUFS3 HTT 3396/4885KHK 2342/4885MET 3850/4885
US-12358903-B2 FXR (NR1H4) modulating compounds NR1H4, NR1H2, NR1H3 HTT 3589/4885KHK 4069/4885MET 130/4885
US-20260078119-A1 DEGRADER COMPOUNDS AND USES THEREOF CTTN, SRC, PTK2 HTT 611/4885KHK 1806/4885MET 6/4885
US-20240199611-A1 ANTIBACTERIAL COMPOUNDS FDPS, MT-ND4, NDUFS3 HTT 3396/4885KHK 2342/4885MET 3850/4885
US-20240182495-A1 ANTIBACTERIAL COMPOUNDS FDPS, MT-ND4, NDUFS3 HTT 3396/4885KHK 2342/4885MET 3850/4885
US-20260055094-A1 FXR (NR1H4) MODULATING COMPOUNDS NR1H4, NR1H2, NR1H3 HTT 3988/4885KHK 3719/4885MET 105/4885
US-20110306636-A1 OXAZOLE PYRIDINE DERIVATIVES USEFUL AS S1P1 RECEPTOR AGONISTS S1PR1, S1PR3, S1PR5 HTT 4740/4885KHK 3375/4885MET 2227/4885
US-20140080808-A1 TETRAHYDROTHIAZEPINE DERIVATIVE HSD11B1, HSD11B2, HSD3B1 HTT 3789/4885KHK 1725/4885MET 3098/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.