Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.44 |
| ▸ | TEK | Q02763 | 2/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | IGF2BP2 | Q9Y6M1 | 1/20 | 0.38 |
| ▸ | TGM2 | P21980 | 3/20 | 0.38 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.37 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30511169 | 0.80 | TGM2 (0.54) | ALDH1A1TEAD1TEKEPHB4FGFR4 | |
| SCHEMBL23037016 | 0.80 | TGM2 (0.54) | ALDH1A1TEAD1TEKEPHB4FGFR4 | |
| SCHEMBL1269021 | 0.78 | TGM2 (0.50) | ALDH1A1TEKFGFR4EGFRITK | |
| SCHEMBL15941656 | 0.77 | GAA (0.48) | GAAALDH1A1POLBTHRBTEAD1 | |
| SCHEMBL23044925 | 0.75 | ALDH1A1 (0.46) | GAAALDH1A1POLBTHRBTEAD1 | |
| SCHEMBL7071749 | 0.75 | CHEK1 (0.41) | GAAALDH1A1POLBTHRBKMT2A | |
| SCHEMBL23060201 | 0.74 | GSTO1 (0.47) | GAAALDH1A1POLBTHRBTEAD1 | |
| SCHEMBL30459766 | 0.73 | KMT2A (0.68) | ALDH1A1TEKEPHB4KMT2AEPHX2 | |
| SCHEMBL17260094 | 0.72 | NPC1 (0.38) | GAAKMT2AKDM4E | |
| SCHEMBL30684939 | 0.71 | EGFR (0.65) | GAAALDH1A1TEKEPHB4EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106536512-B | Carboxamides derivatives | 诺华股份有限公司 | 2019-06-07 | — | — | CN | disclosed |
| EP-3143014-B1 | CARBOXAMIDE DERIVATIVES | NOVARTIS AG (CH) | 2018-10-24 | — | — | EP | disclosed |
| US-9931319-B2 | Carboxamide derivatives | NOVARTIS AG (CH) | 2018-04-03 | — | — | US | disclosed |
| EP-3143014-A1 | CARBOXAMIDE DERIVATIVES | Novartis AG (CH) | 2017-03-22 | — | — | EP | disclosed |
| US-20170000770-A1 | CARBOXAMIDE DERIVATIVES | NOVARTIS AG (CH) | 2017-01-05 | — | — | US | disclosed |
| US-9403833-B2 | Carboxamide derivatives | NOVARTIS AG (CH) | 2016-08-02 | — | — | US | disclosed |
| WO-2015177646-A1 | CARBOXAMIDE DERIVATIVES | NOVARTIS AG (CH) | 2015-11-26 | — | — | WO | disclosed |
| US-20150329549-A1 | CARBOXAMIDE DERIVATIVES | NOVARTIS AG (CH) | 2015-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170000770-A1 | CARBOXAMIDE DERIVATIVES | SIRT5, SIRT7, ADCY5 | GAA 919/4885ALDH1A1 350/4885POLB 3845/4885 |
| US-20150329549-A1 | CARBOXAMIDE DERIVATIVES | CNR2, SIRT7, SLC5A2 | GAA 1354/4885ALDH1A1 821/4885POLB 4299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.