Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | DNM2 | P50570 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8707780 | 0.98 | SMN1; SMN2 (0.42) | SMN1; SMN2ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL11123645 | 0.98 | SMN1; SMN2 (0.42) | SMN1; SMN2ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL11123146 | 0.98 | SMN1; SMN2 (0.42) | SMN1; SMN2ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL11125149 | 0.94 | SMN1; SMN2 (0.49) | SMN1; SMN2ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL11121805 | 0.89 | SMN1; SMN2 (0.41) | SMN1; SMN2ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL9558829 | 0.88 | ADRA2A (0.46) | SMN1; SMN2ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL11123565 | 0.88 | SMN1; SMN2 (0.40) | SMN1; SMN2ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL11127867 | 0.88 | SMN1; SMN2 (0.40) | SMN1; SMN2ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL11123731 | 0.88 | SMN1; SMN2 (0.40) | SMN1; SMN2ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL11125378 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178567-B2 | Insecticidal substituted amino heterocyclic and heteroaryl derivatives | FMC CORPORATION (US) | 2012-05-15 | — | — | US | disclosed |
| EP-1960369-B1 | INDANYL-AND TETRAHYDRONAPHTHYL-AMINO-AZOLINE COMPOUNDS FOR COMBATING ANIMAL PESTS | BASF SE (DE) | 2012-01-11 | — | — | EP | disclosed |
| US-7981437-B2 | Indanyl- and tetrahydronaphthyl-amino-azoline compounds for combating animal pests | BASF SE (DE) | 2011-07-19 | — | — | US | disclosed |
| US-20100137385-A1 | Insecticidal Substituted Amino Heterocyclic and Heteroaryl Derivatives | BAYER CROPSCIENCE AG (DE) | 2010-06-03 | — | — | US | disclosed |
| CN-101316824-A | Indanyl-and tetrahydronaphthyl-amino-azoline compounds for combating animal pests | BASF SE (DE) | 2008-12-03 | — | — | CN | disclosed |
| US-20080293569-A1 | Indanyl- and Tetrahydronaphthyl-Amino-Azoline Compounds for Combating Animal Pests | BASF SE (DE) | 2008-11-27 | — | — | US | disclosed |
| EP-1986498-A2 | INSECTICIDAL SUBSTITUTED AMINO HETEROCYCLIC AND HETEROARYL DERIVATIVES | Bayer CropScience AG (DE) | 2008-11-05 | — | — | EP | disclosed |
| EP-1960369-A1 | INDANYL-AND TETRAHYDRONAPHTHYL-AMINO-AZOLINE COMPOUNDS FOR COMBATING ANIMAL PESTS | BASF SE (DE) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007093292-A2 | INSECTICIDAL SUBSTITUTED AMINO HETEROCYCLIC AND HETEROARYL DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2007-08-23 | — | — | WO | disclosed |
| WO-2007060121-A1 | INDANYL-AND TETRAHYDRONAPHTHYL-AMINO-AZOLINE COMPOUNDS FOR COMBATING ANIMAL PESTS | BASF SE (DE) | 2007-05-31 | — | — | WO | disclosed |
| EP-0724439-A1 | USE OF 2-(2-ALKYLPHENYLAMINO)-OXAZOLINES, -THIAZOLINES AND -IMIDAZOLINES AS ALPHA 2 ADRENERGIC AGENTS | Allergan (US) | 1996-08-07 | — | — | EP | disclosed |
| EP-0420606-B1 | Use of 2-cycloalkylamino oxazolines for reducing or maintaining intraocular pressure | ALLERGAN INC (US) | 1996-03-20 | — | — | EP | disclosed |
| WO-1996001813-A1 | CONFORMATIONALLY RIGID BICYCLIC AND ADAMANTANE DERIVATIVES USEFUL AS α2-ADRENERGIC BLOCKING AGENTS | ALLERGAN (US) | 1996-01-25 | — | — | WO | disclosed |
| WO-1995011021-A1 | USE OF 2-(2-ALKYLPHENYLAMINO)-OXAZOLINES, -THIAZOLINES AND -IMIDAZOLINES AS ALPHA 2 ADRENERGIC AGENTS | ALLERGAN (US) | 1995-04-27 | — | — | WO | disclosed |
| US-5252595-A | Method for reducing or maintaining intraocular pressure in the mammalian eye by administering pharmaceutical compositions containing 2-(2-alkylphenylamino)-oxazolines, 2-(2-alkylphenylamino)-thiazolines and 2-(2-alkylphenylamino)-imidazolines | ALLERGAN, INC. (US) | 1993-10-12 | — | — | US | disclosed |
| US-5151440-A | Treatment of glaucoma | ALLERGAN, INC. (US) | 1992-09-29 | — | — | US | disclosed |
| US-5066664-A | Control of intraocular bleeding and pressure | ALLERGAN, INC. (US) | 1991-11-19 | — | — | US | disclosed |
| EP-0030350-B1 | METHOD FOR REDUCING THE TERMINAL CARBOXYL GROUP CONTENT OF A SATURATED POLYESTER, A SATURATED POLYESTER HAVING A REDUCED TERMINAL CARBOXYL GROUP CONTENT, AND A MOLDED ARTICLE COMPOSED OF SUCH A SATURATED POLYESTER | TEIJIN LIMITED (JP) | 1984-10-10 | — | — | EP | disclosed |
| US-4351936-A | COMPRISING ENDCAPPING WITH AN OXAZOLINE OR OXAZINE | TEIJIN LIMITED (JP) | 1982-09-28 | — | — | US | disclosed |
| EP-0030350-A1 | Method for reducing the terminal carboxyl group content of a saturated polyester, a saturated polyester having a reduced terminal carboxyl group content, and a molded article composed of such a saturated polyester | TEIJIN LIMITED (JP) | 1981-06-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137385-A1 | Insecticidal Substituted Amino Heterocyclic and Heteroaryl Derivatives | DDT, AAAS, DDC | SMN1; SMN2 3097/4885ADRA2A 194/4885ADRA2B 118/4885 |
| US-20080293569-A1 | Indanyl- and Tetrahydronaphthyl-Amino-Azoline Compounds for Combating Animal Pests | INMT, AIPL1, AADAT | SMN1; SMN2 4403/4885ADRA2A 1392/4885ADRA2B 875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.