Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 7/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728185 | 0.87 | MAPT (0.55) | MAPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL1727655 | 0.84 | SMN1; SMN2 (0.59) | MAPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL1728196 | 0.82 | LMNA (0.50) | MAPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL1727944 | 0.81 | LRRK2 (0.59) | MAPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL1726674 | 0.79 | NPC1 (0.52) | MAPTSMN1; SMN2LMNARAB9AMEN1 | |
| SCHEMBL1728020 | 0.77 | KMT2A (0.60) | MAPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL1726841 | 0.77 | PHGDH (0.60) | MAPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL5713545 | 0.76 | MAPT (0.67) | MAPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL1727649 | 0.76 | MEN1 (0.60) | MAPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL1726833 | 0.75 | KDM4A (0.60) | MAPTALDH1A1SMN1; SMN2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403499-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | Stemsynergy Therapeutics, Inc (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010101964-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | STEMSYNERGY THERAPEUTICS, INC (US) | 2010-09-10 | — | — | WO | disclosed |